A study of Alfa Feto Protein parameter in Serum and Histological Effects of Pups Liver by SEM in Pregnant Rats Exposed to Overdose of Aminoglycoside antibiotics

Cardiometry Pub Date : 2023-08-25 DOI:10.18137/cardiometry.2023.28.4852

Ariana Ali, N. I. Abdul-Zahra, D. A. Kadhim

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Abstract

The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2022 and February 2022, fifteen female Albino Rats are used. Gentamicin is aminoglycoside antibiotics widely used during pregnancy for treatment the infections. The present study has been intended to show Alfa Feto Protein parameter in serum and the histological effects of gentamicin on pups liver by SEM in female Albino Rats. The females Rats are randomly divided into three main groups, comprising five rats for each group .The control group is given inta peritoneal injection of physiological normal saline and the second and third group are given inta peritoneal injection of gentamicin doses twenty, forty mg/kg/day respectively for 20 days from the first day to the end of experimental allocated for each female.The rats are sacrificed in 20 th (dpc) to study the Alfa Feto Protein parameter in serum and histological effects of gentamicin on pups liver. The physiological study show negative results in all study groups due to absent of malformations in pups and present histological effects in external architecture structure of pups liver compare with control groups. In conclusion; aminoglycoside gentamicin caused histological effects on pupa liver and not absent of malformations in pups due to negative results of Alfa Feto Protein parameter.

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氨基糖苷类抗生素过量妊娠大鼠血清α - Feto蛋白参数及幼崽肝脏组织学影响的扫描电镜研究

该研究于2022年12月至2022年2月在库法大学动物之家/科学院进行，使用了15只雌性白化大鼠。庆大霉素是妊娠期广泛应用的氨基糖苷类抗生素，用于治疗感染。本研究旨在通过扫描电镜观察雌性白化大鼠血清中Alfa Feto蛋白的参数以及庆大霉素对幼鼠肝脏的组织学影响。雌性大鼠随机分为三个主要组，每组5只，对照组腹腔注射生理盐水，第二组和第三组腹腔注射庆大霉素，剂量分别为20、40mg/kg/天，自实验第一天至实验结束，每只雌性各20天。在第20天（dpc）处死大鼠，研究血清中的Alfa Feto蛋白参数和庆大霉素对幼鼠肝脏的组织学影响。生理学研究显示，与对照组相比，由于幼崽没有畸形，所有研究组的结果均为阴性，并且幼崽肝脏的外部结构存在组织学影响。总之；氨基糖苷类庆大霉素对蛹肝造成组织学影响，并且由于Alfa Feto蛋白参数的阴性结果，幼崽没有畸形。

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

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审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.