{"title":"Association between DNMT3b 579G>T polymorphism and susceptibility to gastric cancer risk: A systematic review and an update meta-analysis","authors":"Hossam Hilal el idrissi , Afaf Ennahal","doi":"10.1016/j.mgene.2021.100928","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The DNA methyltransferase 3B (DNMT3B) play a significant role for methylating the intragenic regions of active genes. Findings of previous studies suggested an association between the DNMT3b 579G>T single-nucleotide polymorphism (SNP) and susceptibility to various tumors. However, limited studies have examined the association of DNMT3B 579G>T polymorphism with gastric cancer risk (GC), and their results are contradictory. This meta-analysis was carried out in order to assess this association.</p></div><div><h3>Methodology</h3><p>We conducted a thorough literature search using in PubMed, Science Direct and Google Scholar databases for relevant studies published up to January 14, 2021. A total of 5 studies were identified and included in this work. The pooled odd rates (ORs) with 95%CIs were estimated using a fixed-effect or random-effect model to take into account the heterogeneity between studies.</p></div><div><h3>Results</h3><p>We found no impact of DNMT3B 579G>T polymorphism on gastric cancer under all genetic models: Allelic model [G vs T, odds ratio (OR) = 0.79, 95% confidence of interval (CI): 0.55–1.13, <em>p</em> = 0.20], recessive model [GG vs GT + TT, OR = 0.96, 95% CI: 0.63–1.46, <em>p</em> = 0.86], dominant model [GG + GT vs TT, OR = 0.72, 95% CI: 0.47–1.10, <em>p</em> = 0.13], heterozygous model [GT vs TT, OR = 0.70, 95% CI: 0.45–1.08, <em>p</em> = 0.11] and homozygous model [GT vs TT, OR = 0.72, 95% CI: 0.44–1.17, <em>p</em> = 0.18], homozygous, OR: 0.72, 95% CI = 0.44–1.17, p = 0.18).</p></div><div><h3>Conclusion</h3><p>Our results indicated that DNMT3B 579G>T is not associated with GC, and it may not be used as a stratification marker to predict susceptibility.</p></div>","PeriodicalId":38190,"journal":{"name":"Meta Gene","volume":"29 ","pages":"Article 100928"},"PeriodicalIF":0.8000,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mgene.2021.100928","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Meta Gene","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214540021000797","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Background
The DNA methyltransferase 3B (DNMT3B) play a significant role for methylating the intragenic regions of active genes. Findings of previous studies suggested an association between the DNMT3b 579G>T single-nucleotide polymorphism (SNP) and susceptibility to various tumors. However, limited studies have examined the association of DNMT3B 579G>T polymorphism with gastric cancer risk (GC), and their results are contradictory. This meta-analysis was carried out in order to assess this association.
Methodology
We conducted a thorough literature search using in PubMed, Science Direct and Google Scholar databases for relevant studies published up to January 14, 2021. A total of 5 studies were identified and included in this work. The pooled odd rates (ORs) with 95%CIs were estimated using a fixed-effect or random-effect model to take into account the heterogeneity between studies.
Results
We found no impact of DNMT3B 579G>T polymorphism on gastric cancer under all genetic models: Allelic model [G vs T, odds ratio (OR) = 0.79, 95% confidence of interval (CI): 0.55–1.13, p = 0.20], recessive model [GG vs GT + TT, OR = 0.96, 95% CI: 0.63–1.46, p = 0.86], dominant model [GG + GT vs TT, OR = 0.72, 95% CI: 0.47–1.10, p = 0.13], heterozygous model [GT vs TT, OR = 0.70, 95% CI: 0.45–1.08, p = 0.11] and homozygous model [GT vs TT, OR = 0.72, 95% CI: 0.44–1.17, p = 0.18], homozygous, OR: 0.72, 95% CI = 0.44–1.17, p = 0.18).
Conclusion
Our results indicated that DNMT3B 579G>T is not associated with GC, and it may not be used as a stratification marker to predict susceptibility.
Meta GeneBiochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍:
Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.