Outcome of long-term cognitive function after liver transplantation in children: role of age factor

Q4 Medicine

中华麻醉学杂志 Pub Date : 2019-10-20 DOI:10.3760/CMA.J.ISSN.0254-1416.2019.10.005

Hui Zhu, Xuliang Jiang, Lili Huang, Xiao Zhang, W. Tian, D. Su, Weifeng Yu

{"title":"Outcome of long-term cognitive function after liver transplantation in children: role of age factor","authors":"Hui Zhu, Xuliang Jiang, Lili Huang, Xiao Zhang, W. Tian, D. Su, Weifeng Yu","doi":"10.3760/CMA.J.ISSN.0254-1416.2019.10.005","DOIUrl":null,"url":null,"abstract":"Objective \nTo evaluate the outcome of long-term cognitive function after liver transplantation in children and the role of age factor. \n \n \nMethods \nNinety-five pediatric patients, aged 2 yr and 6 months to 6 yr and 11 months at test, at least 1 yr after liver transplantation, were selected.The children′s cognitive function was assessed using Chinese Wechsler Intelligence Scale for Children.The patients were divided into 2 groups according to the age at transplantation: ≤1 yr group (L1 group, n=65) and > 1 yr group (M1 group, n=22). \n \n \nResults \nCompared with the normal value, the scores of verbal comprehension and total intelligence quotient (IQ) were significantly decreased, and the proportion of children who had above-average IQ was decreased 1 yr after liver transplantation, the scores of verbal comprehension were decreased, and the proportion of children who had above-average IQ was decreased in group L1, and the scores of verbal comprehension, visual space and total IQ were significantly decreased, the proportion of children who had above-average IQ was reduced, and the proportion of children who had below-average IQ was increased in group M1(P<0.05). Compared with L1 group, the total IQ score was significantly decreased, the proportion of children who had above-average IQ was reduced, and the proportion of children who had below-average IQ was increased in group M1 (P<0.05). \n \n \nConclusion \nThe long-term cognitive function of children after liver transplantation is lower than that of normal children, and the long-term cognitive function of children ≤1 yr is better than that of children >1 yr. \n \n \nKey words: \nLiver transplantation; Cognition; Child; Age factors","PeriodicalId":10053,"journal":{"name":"中华麻醉学杂志","volume":"39 1","pages":"1165-1167"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华麻醉学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.0254-1416.2019.10.005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To evaluate the outcome of long-term cognitive function after liver transplantation in children and the role of age factor. Methods Ninety-five pediatric patients, aged 2 yr and 6 months to 6 yr and 11 months at test, at least 1 yr after liver transplantation, were selected.The children′s cognitive function was assessed using Chinese Wechsler Intelligence Scale for Children.The patients were divided into 2 groups according to the age at transplantation: ≤1 yr group (L1 group, n=65) and > 1 yr group (M1 group, n=22). Results Compared with the normal value, the scores of verbal comprehension and total intelligence quotient (IQ) were significantly decreased, and the proportion of children who had above-average IQ was decreased 1 yr after liver transplantation, the scores of verbal comprehension were decreased, and the proportion of children who had above-average IQ was decreased in group L1, and the scores of verbal comprehension, visual space and total IQ were significantly decreased, the proportion of children who had above-average IQ was reduced, and the proportion of children who had below-average IQ was increased in group M1(P<0.05). Compared with L1 group, the total IQ score was significantly decreased, the proportion of children who had above-average IQ was reduced, and the proportion of children who had below-average IQ was increased in group M1 (P<0.05). Conclusion The long-term cognitive function of children after liver transplantation is lower than that of normal children, and the long-term cognitive function of children ≤1 yr is better than that of children >1 yr. Key words: Liver transplantation; Cognition; Child; Age factors

查看原文本刊更多论文

儿童肝移植术后长期认知功能的预后:年龄因素的作用

目的探讨儿童肝移植术后长期认知功能的预后及年龄因素的影响。方法选取肝移植术后至少1年，年龄为2岁6个月~ 6岁11个月的患儿95例。采用《中国儿童韦氏智力量表》对儿童的认知功能进行评估。根据患者移植年龄分为2组:≤1年组(L1组，n=65)和> 1年组(M1组，n=22)。结果与正常值比较，L1组患儿的言语理解、总智商(IQ)得分显著下降，且肝移植后1年智商高于平均水平的患儿比例下降，L1组患儿的言语理解得分下降，智商高于平均水平的患儿比例下降，言语理解、视觉空间、总智商得分显著下降;M1组智商高于平均水平的比例降低，智商低于平均水平的比例增加。关键词:肝移植;认知;孩子;年龄因素

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊