Seroprevalence and associated factors of hepatitis B virus infection among HIV-positive adults attending an antiretroviral treatment clinic at Wolaita Sodo University Referral Hospital

IF 2.6 Q2 GASTROENTEROLOGY & HEPATOLOGY

Hepatic Medicine : Evidence and Research Pub Date : 2019-09-01 DOI:10.2147/HMER.S206870

Abraham Goa, Tadele Dana, Shimelash Bitew, Aseb Kinfe Arba

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引用次数: 9

Abstract

Background Hepatitis B virus infection (HBV) constitutes major public health problems in sub-Saharan Africa from different infections occuring in HIV positive patients. Ethiopia is a part of sub-Saharan Africa with 1.5% adult HIV prevalence, and also belongs to the intermediate to high HBV prevalence category. Hence, this study aimed to measure the seroprevalence and associated factors of HBV infection among HIV-positive adults attending an antiretroviral treatment (ART) clinic at Wolaita Sodo University Referral Hospital. Methods An institution-based cross-sectional study was conducted from October 15 to December 10, 2017 using a systematic random sampling technique. After getting informed written consent, data were collected by a structured and interviewer-administered questionnaire. Venous blood was collected and centrifuged to separate serum. Hepatitis B surface antigen (HBsAg) was detected from serum using an advanced quality one-step rapid test kit. Data were entered into EpiData version 3.01 and exported to SPSS version 20. Summary statistics, bivariate analysis, and multivariate analyses were performed. The variables having significant association of P<0.05 in the multivariate logistic regression were taken as independent factors. OR and 95% CI were used to measure the strength of the association. Results A total of 442 study participants, 187 males and 255 females, were included in this study. Overall prevalence of HBsAg was 37 (8.4%). Family history of HBV (adjusted OR=8.83, 95% CI=2.56–30.49), multiple sexual partners (adjusted OR=7.08, 95% CI=2.29–21.9), and CD4 count <200 cells/μL (adjusted OR=15.34, 95% CI=4.77–49.3) were found to be significantly associated with HBsAg positivity. Conclusion The prevalence of HBsAg in this study was high. Family history of HBV, multiple sexual partners, and CD4 count <200 cells/μL were independently associated with HBsAg positivity. Therefore, screening for HBV is recommended before initiation of ART in HIV patients and providing appropriate treatment for co-infection. Furthermore, accurate information on risk factors for HBV transmission should be provided.

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在Wolaita Sodo大学转诊医院接受抗逆转录病毒治疗的艾滋病毒阳性成人中乙型肝炎病毒感染的血清阳性率和相关因素

背景:乙型肝炎病毒感染(HBV)是撒哈拉以南非洲主要的公共卫生问题，原因是艾滋病毒阳性患者发生不同的感染。埃塞俄比亚是撒哈拉以南非洲的一部分，成人艾滋病毒患病率为1.5%，也属于HBV中高患病率类别。因此，本研究旨在测量在Wolaita Sodo大学转诊医院抗逆转录病毒治疗(ART)诊所就诊的hiv阳性成人中HBV感染的血清阳性率和相关因素。方法采用系统随机抽样方法，于2017年10月15日至12月10日进行基于机构的横断面研究。在获得知情的书面同意后，通过结构化和访谈者管理的问卷收集数据。采集静脉血，离心分离血清。采用先进质量的一步快速检测试剂盒从血清中检测乙型肝炎表面抗原(HBsAg)。数据输入EpiData 3.01版本，导出到SPSS 20版本。进行汇总统计、双变量分析和多变量分析。多因素logistic回归中P<0.05有显著相关性的变量作为独立因素。OR和95% CI用于测量相关性的强度。结果共纳入442名研究对象，其中男性187人，女性255人。HBsAg总患病率为37(8.4%)。HBV家族史(调整后OR=8.83, 95% CI=2.56 ~ 30.49)、多个性伴侣(调整后OR=7.08, 95% CI=2.29 ~ 21.9)、CD4计数<200 cells/μL(调整后OR=15.34, 95% CI=4.77 ~ 49.3)与HBsAg阳性有显著相关性。结论本研究人群HBsAg患病率较高。HBV家族史、多个性伴侣、CD4计数<200细胞/μL与HBsAg阳性独立相关。因此，建议在艾滋病毒患者开始抗逆转录病毒治疗之前进行HBV筛查，并为合并感染提供适当的治疗。此外，应提供有关HBV传播危险因素的准确信息。

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来源期刊

Hepatic Medicine : Evidence and Research GASTROENTEROLOGY & HEPATOLOGY-

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0.00%

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审稿时长

16 weeks

期刊介绍： Hepatic Medicine: Evidence and Research is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of adult and pediatric hepatology in the clinic and laboratory including the following topics: Pathology, pathophysiology of hepatic disease Investigation and treatment of hepatic disease Pharmacology of drugs used for the treatment of hepatic disease Although the main focus of the journal is to publish research and clinical results in humans; preclinical, animal and in vitro studies will be published where they will shed light on disease processes and potential new therapies. Issues of patient safety and quality of care will also be considered. As of 1st April 2019, Hepatic Medicine: Evidence and Research will no longer consider meta-analyses for publication.