COVID-19 in newborns and in children: the state of the art

IF 0.3 Q4 PEDIATRICS

Journal of Pediatric and Neonatal Individualized Medicine Pub Date : 2020-03-28 DOI:10.7363/090138

Valentina Paraluppi, Maria Cristina Pintus, V. Fanos, M. A. Marcialis

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引用次数: 15

Abstract

Novel COronaVIrus Disease 2019 (COVID-19) is an emerging disease of public health concern because it is caused by a newly identified pathogen, against which humans have no pre-existing immunity. Since its outbreak, a growing number of studies have examined COVID-19 in adults, but the data on its epidemiological and clinical characteristics in newborns and in children are few and patchy. Children appear to develop moderate-mild or silent forms of the disease; to our knowledge, only two cases of death (a 14-year-old and a 16-year-old teenagers) have been reported. Arguably, the number of pediatric cases may be underestimated, since presumably cases with mild or no symptoms are not brought to the doctor’s attention. We have selected the most interesting and significant papers (including some pre-publication or ahead-of-print papers). The key factors in the pathophysiology of COVID-19, available data on pregnancy, the neonatal period, and later are discussed. A review of pediatric cases is available and 3 practical algorithms help the reader in clinical choices. Finally, diagnostic criteria and treatment are presented.

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新生儿和儿童中的COVID-19:最新进展

2019年新型冠状病毒病（新冠肺炎）是一种新出现的公共卫生疾病，因为它是由一种新发现的病原体引起的，而人类对这种病原体没有预先存在的免疫力。自疫情爆发以来，越来越多的研究对成人新冠肺炎进行了检测，但有关其在新生儿和儿童中的流行病学和临床特征的数据很少且不完整。儿童出现中度轻度或无症状的疾病；据我们所知，只报告了两例死亡病例（一名14岁和一名16岁的青少年）。可以说，儿科病例的数量可能被低估了，因为可能症状轻微或无症状的病例不会引起医生的注意。我们选择了最有趣和最重要的论文（包括一些出版前或出版前的论文）。讨论了新冠肺炎病理生理学中的关键因素、妊娠、新生儿期和后期的可用数据。儿科病例综述可用，3种实用算法有助于读者进行临床选择。最后，提出了诊断标准和治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric and Neonatal Individualized Medicine PEDIATRICS-

CiteScore

1.00

自引率

25.00%

发文量

审稿时长

12 weeks

期刊介绍： The Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) is a peer-reviewed interdisciplinary journal which provides a forum on new perspectives in pediatric and neonatal medicine. The aim is to discuss and to bring readers up to date on the latest in research and clinical pediatrics and neonatology. Special emphasis is on developmental origin of health and disease or perinatal programming and on the so-called ‘-omic’ sciences. Systems medicine blazes a revolutionary trail from reductionist to holistic medicine, from descriptive medicine to predictive medicine, from an epidemiological perspective to a personalized approach. The journal will be relevance to clinicians and researchers concerned with personalized care for the newborn and child. Also medical humanities will be considered in a tailored way. Article submission (original research, review papers, invited editorials and clinical cases) will be considered in the following fields: fetal medicine, perinatology, neonatology, pediatrics, developmental programming, psychology and medical humanities.