Application of Diffusion Tensor Imaging in the Evaluation of Brain Injury in Premature Infants with Low and Very Low Birth Weight

IF 0.2 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Iranian Journal of Radiology Pub Date : 2021-09-21 DOI:10.5812/iranjradiol.112648

Dalin Zhu, Manxia Wang, F. Feng, Nan Nan, Yuefen Liu, Jinyun Shi, B. Mao

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引用次数: 0

Abstract

Background: Brain injury in premature infants (BIPI) is a severe brain damage in premature infants, resulting in a series of neurological sequelae. Diffusion tensor imaging (DTI), as a magnetic resonance imaging (MRI) technique, is more widely used for premature infants. It is of paramount importance to improve the early diagnosis, treatment, and intervention for this population by using DTI. There are few reports on the application of DTI for the evaluation of BIPI in low-birth-weight (LBW) and very-low-birth-weight (VLBW) infants. Objectives: To analyze the clinical characteristics of BIPI in LBW and VLBW infants and to explore the value of MRI-based DTI in the evaluation of BIPI in LBW infants. Patients and Methods: This prospective study was conducted on 31 cases of BIPI (16 LBW and 15 VLBW infants) and 20 normal control premature infants, undergoing MRI-based DTI at the postmenstrual age (PMA). Differences in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) between the BIPI and control groups and also between the LBW and VLBW groups with BIPI were analyzed. Also, differences with normal controls in terms of the FA and ADC values were investigated in different brain regions. Results: The FA values in the central white matter of the frontal lobe, central white matter of the occipital lobe, centrum semiovale, posterior limb of the internal capsule (PLIC), and ventral thalamus were significantly lower in the BIPI group as compared to the control group (P < 0.05). The ADCs were lower in the BIPI group compared to the control group, and there was a significant difference (P < 0.05). Comparison of FA and ADC values in the central white matter of the frontal lobe, central white matter of the occipital lobe, centrum semiovale, PLIC, and ventral thalamus did not show any significant differences between the LBW and VLBW groups with BIPI (P > 0.05). Conclusion: The FA and ADC values of DTI can be used for the quantitative evaluation of BIPI in LBW and VLBW infants. The FA value was found to be more accurate than the ADC. Overall, different FA values in different brain areas reflect differences in the brain development of normal premature infants.

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弥散张量成像在低、极低出生体重早产儿脑损伤评价中的应用

背景：早产儿脑损伤（BIPI）是一种严重的早产儿脑损伤，导致一系列神经系统后遗症。弥散张量成像（DTI）作为一种磁共振成像（MRI）技术，在早产儿中得到了更广泛的应用。通过DTI改善这一人群的早期诊断、治疗和干预至关重要。关于DTI应用于低出生体重（LBW）和极低出生重量（VLBW）婴儿BIPI评估的报道很少。目的：分析LBW和VLBW婴儿BIPI的临床特征，探讨基于MRI的DTI在评估LBW婴儿BIPI中的价值。患者和方法：本前瞻性研究对31例BIPI（16例LBW和15例VLBW婴儿）和20例正常对照早产儿进行了月经后年龄（PMA）的MRI DTI检查。分析了BIPI组和对照组之间以及患有BIPI的LBW组和VLBW组之间的分数各向异性（FA）和表观扩散系数（ADC）的差异。此外，研究了不同脑区FA和ADC值与正常对照组的差异。结果：与对照组相比，BIPI组额叶中央白质、枕叶中心白质、半卵圆孔、内囊后肢（PLIC）和腹侧丘脑的FA值显著降低（P<0.05），额叶中央白质、枕叶中央白质和半卵圆中心、PLIC的FA和ADC值比较，结论：DTI的FA和ADC值可用于定量评价LBW和VLBW婴儿的BIPI。发现FA值比ADC更准确。总的来说，不同大脑区域的FA值不同，反映了正常早产儿大脑发育的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Iranian Journal of Radiology is the official journal of Tehran University of Medical Sciences and the Iranian Society of Radiology. It is a scientific forum dedicated primarily to the topics relevant to radiology and allied sciences of the developing countries, which have been neglected or have received little attention in the Western medical literature. This journal particularly welcomes manuscripts which deal with radiology and imaging from geographic regions wherein problems regarding economic, social, ethnic and cultural parameters affecting prevalence and course of the illness are taken into consideration. The Iranian Journal of Radiology has been launched in order to interchange information in the field of radiology and other related scientific spheres. In accordance with the objective of developing the scientific ability of the radiological population and other related scientific fields, this journal publishes research articles, evidence-based review articles, and case reports focused on regional tropics. Iranian Journal of Radiology operates in agreement with the below principles in compliance with continuous quality improvement: 1-Increasing the satisfaction of the readers, authors, staff, and co-workers. 2-Improving the scientific content and appearance of the journal. 3-Advancing the scientific validity of the journal both nationally and internationally. Such basics are accomplished only by aggregative effort and reciprocity of the radiological population and related sciences, authorities, and staff of the journal.