M. Dună, D. Predețeanu, F. Berghea, M. Abobului, V. Vlad, A. Balanescu, D. Opriș-Belinski, C. Constantinescu, A. Borangiu, L. Groșeanu, I. Saulescu, M. Negru, S. Daia, D. Mazilu, R. Ionescu, B. Pharmacy
{"title":"General characteristics and familial aggregation in patients with systemic lupus erythematosus","authors":"M. Dună, D. Predețeanu, F. Berghea, M. Abobului, V. Vlad, A. Balanescu, D. Opriș-Belinski, C. Constantinescu, A. Borangiu, L. Groșeanu, I. Saulescu, M. Negru, S. Daia, D. Mazilu, R. Ionescu, B. Pharmacy","doi":"10.37897/rjr.2018.3.5","DOIUrl":null,"url":null,"abstract":"Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which deposit within tissues and fix complement leading to systemic inflammation (1). Is a heterogeneous disease with a continuum of disease activity. Some patients can have predominant skin and joint involvement, whereas others can present with organ-threatening diseases such as nephritis, cardiac involvement or even neurologic manifestations. Relatives of patients with SLE appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable (2,3).","PeriodicalId":33518,"journal":{"name":"Revista Romana de Reumatologie","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Romana de Reumatologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37897/rjr.2018.3.5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which deposit within tissues and fix complement leading to systemic inflammation (1). Is a heterogeneous disease with a continuum of disease activity. Some patients can have predominant skin and joint involvement, whereas others can present with organ-threatening diseases such as nephritis, cardiac involvement or even neurologic manifestations. Relatives of patients with SLE appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable (2,3).
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