Progress in mucosal immune of female reproductive tract

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2020-03-31 DOI:10.3760/CMA.J.CN112309-20190710-00211

Huihui Wang, Wenhui Qi, Xingshuo Li, A. Fan, Cha Han, F. Xue

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引用次数: 0

Abstract

The mucosal immune system is the first line of defense against pathogens such as bacteria and viruses invading the bodies. The female reproductive tract mucosal immune system not only resists the invasion of pathogens through innate and adaptive immunity, but also contribute to successfully fertilization and pregnancy, thus maintaining the health of women′s reproductive system. The innate immunity of female genital tract involves the mechanical barrier of the mucosal epithelium, microbial barrier of commensal bacteria, immunological barrier of immune cells and their receptors, and adaptive immunity including B cell-mediated humoral immunity and T cell-mediated cellular immunity. Female genital mucosal immunity is not only involved in local inflammation, but may also have anti-tumor effects. Moreover, the female genital tract mucosal immune is also regulated by sex hormone to maintain a homeostasis of local microenvironment. Herein, this paper summarized recent progress in female genital mucosal immunity. Key words: Mucosal immune; Female reproductive tract; Innate immunity; Adaptive immunity; Commensal bacteria; Sex hormone

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女性生殖道黏膜免疫研究进展

粘膜免疫系统是抵御细菌和病毒等病原体入侵人体的第一道防线。女性生殖道粘膜免疫系统不仅通过先天免疫和适应性免疫抵抗病原体的入侵，而且有助于成功受精和怀孕，从而维护女性生殖系统的健康。女性生殖道的先天免疫包括粘膜上皮的机械屏障、共生菌的微生物屏障、免疫细胞及其受体的免疫屏障，以及包括B细胞介导的体液免疫和T细胞介导细胞免疫在内的适应性免疫。女性生殖器黏膜免疫不仅参与局部炎症，还可能具有抗肿瘤作用。此外，女性生殖道粘膜免疫也受到性激素的调节，以维持局部微环境的稳态。本文综述了近年来女性生殖道黏膜免疫的研究进展。关键词：黏膜免疫；女性生殖道；先天免疫；适应性免疫；共生菌；性激素

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.