Is the microRNA-221/222 Cluster Ushering in a New Age of Cardiovascular Diseases?

Abstract

In addition to regulating gene expression, microRNAs (MiRs) regulate messenger RNA degradation and translation rates. MiRs have a high expression in the cardiovascular (CV) system, indicating an important role in vascular health. The atherosclerotic process has been related to miRs-221 and -222. MiRs-221/222 possess anti-stenotic activity. MiR-221/222 may potentially serve as a marker for myocardial remodeling. There is still a long way yet before miRs-221/222 can be recognized as a potential therapeutic target. Identifi cation, validation, and understanding of the function of gene targets are all critical. Klíčová slova: Kardiovaskulární systém MikroRNA MiR-221/222 Působení proti tvorbě stenóz Remodelace