Study on tau related disease pattern of Alzheimer′s disease based on 18F-APN-1607 PET imaging

中华核医学与分子影像杂志 Pub Date : 2020-04-25 DOI:10.3760/CMA.J.CN321828-20200205-00034

Jian-Fang Ning, Jiehui Jiang, Chunhua Liu, Wei-qi Bao, Ming Li, Jiaying Lu, Ling Li, C. Zuo, Y. Guan

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Abstract

Objective Exploring tau related disease pattern (tauRDP) in the brain of Alzheimer′s disease (AD) patients based on 18F-APN-1607 PET scan. Methods 18F-APN-1607 PET images were collected from 17 AD patients (6 males and 11 females, age: (61.7±12.3) years, Mini-Mental State Examination (MMSE) score: 17.6±7.9) and 10 normal controls (NC; 6 males and 4 females, age: (61.2±4.7) years) from Huashan Hospital of Fudan University. The scaled subprofile model (SSM) based on principal component analysis (PCA) technique was used to construct the tauRDP. Then the expression value of tauRDP in each sample was calculated. The differences on tauRDP expression values between AD patients and NC were compared by independent-sample t test. Pearson correlation analysis was used to analyze the correlation between tauRDP expression values and MMSE values in AD patients. Results The tauRDP area mainly included: precentral gyrus, dorsolateral superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus of opercular part, inferior frontal gyrus of triangular part, supplementary motor area, medial superior frontal gyrus, left median cingulate and paracingulate gyri, right cuneus, superior occipital gyrus, middle occipital gyrus, postcentral gyrus, superior parietal gyrus inferior parietal, but supramarginal and angular gyri, supramarginal gyrus, angular gyrus, precuneus and middle temporal gyrus. There were significant differences (t=4.395, P<0.001) between AD group (12.6±8.0) and NC group (0.0±1.0) in tauRDP expression values. The tauRDP expression values were correlated with MMSE values in AD group significantly (r=-0.566, P=0.018). Conclusions TauRDP established basing on SSM/PCA method can be used to quantitatively express the abnormal spatial distributions of tau deposition. Expression value of tauRDP has the potential to initially assess the severity of AD. Key words: Alzheimer disease; Tau proteins; Benzothiazoles; Positron-emission tomography

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基于18F-APN-1607 PET成像的阿尔茨海默病tau相关疾病模式研究

目的基于18F-APN-1607 PET扫描，探讨阿尔茨海默病（AD）患者大脑中tau相关疾病模式（tauRDP）。方法收集复旦大学华山医院17例AD患者（男6例，女11例，年龄：（61.7±12.3）岁，简易精神状态检查（MMSE）评分：17.6±7.9）和10例正常对照（NC；男6例、女4例，年龄（61.2±4.7）岁）的18F-APN-1607 PET图像。使用基于主成分分析（PCA）技术的缩放子文件模型（SSM）来构建tauRDP。然后计算每个样品中tauRDP的表达值。通过独立样本t检验比较AD患者和NC患者之间tauRDP表达值的差异。采用Pearson相关分析法分析AD患者tauRDP表达值与MMSE值之间的相关性。结果tauRDP区主要包括：中央前回、额上背外侧回、额中回、额盖部额下回、三角部额下回、辅助运动区、额中上回、左中扣带和扣带旁回、右楔、枕上回、枕中回、中央后回，顶叶上回顶叶下回，但缘上回和角回、缘上回、角回、楔前叶和颞中回。tauRDP表达值在AD组（12.6±8.0）和NC组（0.0±1.0）之间存在显著差异（t=4.395，P<0.001）。AD组tauRDP表达值与MMSE值显著相关（r=-0.566，P=0.018）。结论基于SSM/PCA方法建立的tauRDP可用于定量表达tau沉积的异常空间分布。tauRDP的表达值具有初步评估AD严重程度的潜力。关键词：阿尔茨海默病；Tau蛋白；苯并噻唑；正电子发射断层扫描

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

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发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.