Analysis of the clinical characteristics of retinopathy in multiple premature infants

Q4 Medicine

中华眼底病杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1005-1015.2020.02.009

Shuhui Chen, Min Zhang, Minyu Chen

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引用次数: 0

Abstract

Objective To observe the clinical features of retinopathy of prematurity (ROP) in multiple fetuses. Methods Retrospective clinical study. From December 2009 to June 2018, 758 premature or low-weight multiple fetuses (multiple fetuses group) and 2363 simultaneous single fetuses (single fetuses group) who were admitted to the Department of Ophthalmology and Neonatal Department of Dongguan People’s Hospital and underwent ROP screening were included in the study. Among the multiple pregnancy group, there were 735 twins and 23 triplets; 441 males and 317 females. The mean gestational age was 32.22±2.14 weeks, and the mean body weight was 1.69±0.43 kg. There were 202 of natural births and 556 of cesarean sections. A total of 750 cases have a history of oxygen. Among the singleton group, 1421 were males and 942 were females. The mean gestational age was 32.06±2.52 weeks, and the mean body weight was 1.70±0.46 kg. There were 1146 of natural births and 1217 of cesarean sections. A total of 2333 cases have a history of oxygen. The detection rate of multiple ROP, gestational age, birth weight, sex composition ratio, mode of birth, time of first ROP diagnosis, and severity of ROP were observed. χ2 test was used to compare the rate between groups, and t test was used to compare the mean between groups. Results Among the multiple pregnancy group, there were 68 cases (8.97%) of ROP. Among them, 64 twins (8.71%, 64/735), 4 triplets (17.39%, 4/23). Among the singleton group, there were 187 cases (7.91%) of ROP. With the increase of fetal number, the detection rate of ROP increased, but there was no significant difference (χ2=3.097, P=0.213). There was no significant difference in the detection rate of ROP between multiple fetuses and single fetuses (χ2=0.855, P=0.355). There was no significant difference in sex ratio (χ2=0.069), mode of production (χ2=1.900), birth weight (t=0.139), gestational age (t=-0.478), and time of first ROP diagnosis (t=0.371) between ROP cases of multiple fetuses and single fetuses (P=0.793, 0.168, 0.889, 0.633, 0.371). There was no significant difference in the constituent ratio of severity of ROP lesions between multiple fetuses and single fetuses (χ2=3.003, P=0.223). Conclusion There is no significant difference in ROP incidence, gestational age, birth weight, diagnosis time and severity of ROP between multiple fetuses and single fetuses under the same conditions. Key words: Retinopathy of prematurity; Pregnancy, multiple; Neonatal screening

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多发性早产儿视网膜病变的临床特点分析

目的观察多胎早产儿视网膜病变（ROP）的临床特点。方法回顾性临床研究。2009年12月至2018年6月，在东莞市人民医院眼科和新生儿科住院并接受ROP筛查的758例早产或低体重多胎（多胎组）和2363例同期单胎（单胎组）纳入研究。多胎妊娠组中，双胞胎735例，三胞胎23例；441名男性和317名女性。平均胎龄32.22±2.14周，平均体重1.69±0.43 kg，顺产202例，剖宫产556例。共有750例患者有吸氧史。在单胎组中，1421人为男性，942人为女性。平均胎龄32.06±2.52周，平均体重1.70±0.46 kg，顺产1146例，剖宫产1217例。共有2333例有吸氧史。观察多发性ROP的检出率、胎龄、出生体重、性别构成比、出生方式、首次诊断ROP的时间和ROP的严重程度。χ2检验用于比较各组间的发生率，t检验用于比较组间的平均值。结果多胎妊娠组ROP 68例，占8.97%。其中双胞胎64例（8.71%，64/735），三胞胎4例（17.39%，4/23）。在单例组中，有187例（7.91%）ROP。随着胎儿数量的增加，ROP的检出率增加，但无显著性差异（χ2=3.097，P=0.213）。多胎和单胎ROP检出率无显著性差别（χ2=0.855，P=0.355）。性别比（χ2=0.069）、生产方式（χ2=1.900）、出生体重（t=0.139），胎龄（t=-0.478），多胎和单胎ROP首次诊断时间（t=0.371）（P=0.793，0.168，0.889，0.633，0.371），胎龄、出生体重、诊断时间以及在相同条件下多胎和单胎ROP的严重程度。关键词：早产儿视网膜病变；妊娠，多胎；新生儿筛查

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来源期刊

中华眼底病杂志 Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

5383

期刊介绍： Chinese Journal of Ocular Fundus Diseases is the only scientific journal in my country that focuses on reporting fundus diseases. Its purpose is to combine clinical and basic research, and to give equal importance to improvement and popularization. It comprehensively reflects the leading clinical and basic research results of fundus disease disciplines in my country; cultivates professional talents in fundus disease, promotes the development of fundus disease disciplines in my country; and promotes academic exchanges on fundus disease at home and abroad. The coverage includes clinical and basic research results of posterior segment diseases such as retina, uveal tract, vitreous body, visual pathway, and internal eye diseases related to systemic diseases. The readers are medical workers and researchers related to clinical and basic research of fundus diseases. According to the journal retrieval report of the Chinese Institute of Scientific and Technological Information, the comprehensive ranking impact factor and total citation frequency of the Chinese Journal of Ocular Fundus Diseases have been among the best in the disciplines of ophthalmology, otolaryngology, and ophthalmology in my country for many years. The papers published have been included in many important databases at home and abroad, such as Scopus, Peking University Core, and China Science Citation Database (CSCD).