Clinical analysis of five cases of demyelinating pseudotumor

Q4 Medicine

中国现代神经疾病杂志 Pub Date : 2017-03-25 DOI:10.3969/CJCNN.V17I3.1566

Fu-rong Gu, Xiao-ling Yan, J. Qin, Xiao-lin Xu

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引用次数: 1

Abstract

Objective To study the clinical manifestations, imaging and pathological features, treatment and prognosis of 5 patients diagnosed as demyelinating pseudotumor (DPT) by pathology. Methods The data of clinical features, radiological and histological examination of 5 patients with DPT were retrospectively analyzed, and relevant literatures were reviewed. Results All patients were male. Main symptoms included limb weakness in 3 cases, dizziness and impaired memory in 2 cases, seizures in one case. Head MRI examination revealed space-occupying lesions with hypointense signal on T 1 WI, hyperintense signal on T 2 WI and FLAIR. Enhanced MRI showed obvious enhancement of lesions (open-ring enhancement in 3 cases). The lesion were totally (4 cases) or partially (one case) removed, and postoperative histological examination showed inflammatory demyelination. One case died after twice relapse, and others had favorable prognosis. Conclusions DPT is an inflammatory demyelination with mass effect. It should be differentiated from central nervous system tumors in order to avoid unnecessary resection or radiotherapy. DOI: 10.3969/j.issn.1672-6731.2017.03.010

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脱髓鞘性假瘤5例临床分析

目的探讨5例病理诊断为脱髓鞘性假瘤(DPT)的临床表现、影像学及病理特征、治疗及预后。方法回顾性分析5例DPT患者的临床表现、影像学及组织学检查资料，并复习相关文献。结果所有患者均为男性。主要症状为肢体无力3例，头晕、记忆障碍2例，癫痫发作1例。头部MRI示占位性病变，t1 WI呈低信号，t2 WI及FLAIR呈高信号。MRI增强显示病灶明显强化(3例开环强化)。病灶全部(4例)或部分(1例)切除，术后组织学检查示炎性脱髓鞘。2次复发1例死亡，其余预后良好。结论DPT是一种具有肿块效应的炎性脱髓鞘。应与中枢神经系统肿瘤鉴别，以避免不必要的切除或放疗。DOI: 10.3969 / j.issn.1672-6731.2017.03.010

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