Ketoconazole 2% cream versus a combination of ketoconazole 2% cream and adapalene 0.1% gel in the treatment of pityriasis versicolor

K. Tawfik, Waleed Mahmmoud, A. Ali
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Abstract

Background and aim Pityriasis versicolor is a common chronic superficial fungal infection that manifests during or after puberty in hot humid temperatures. Topical treatments, which are the first line of treatment, are divided into nonspecific and specific antifungal agents; however, the therapeutic approaches for pityriasis versicolor depend mainly on synthetic antifungal drugs, in particular ketoconazole. However, due to the frequent recurrence of this disease, and the widespread application of azole drugs, resistant strains have emerged leading to increasingly failed treatment rates. Retinoic acid creams are also effective against pityriasis versicolor. Especially adapalene gel that has less irritation compared with other topical retinoid products and also has rapid onset of action. Therefore, we aimed to evaluate the efficacy and safety of a combination treatment of ketoconazole cream 2% and adapalene gel 0.01% in the treatment of pityriasis versicolor. Patients and methods In all, 100 patients were divided equally into two groups: group 1 patients were treated with topical application ketoconazole 2% cream and adapalene 0.1% gel once daily for a total duration of 2 weeks. Group 2 patients were treated with a topical application ketoconazole 2% cream for a total duration of 2 weeks. Results There was significant improvement rates in the combined group than ketoconazole-only group with P value=0.023. Adepalene+ketoconacole group had more irritation as a side effect than the ketoconazole group with significant P value=0.001. Conclusion The combination of adapalene 0.1% gel and ketoconazole 2% cream is safe, rapid, and effective in the treatment of pityriasis versicolor.
2%酮康唑乳膏与2%酮康唑软膏与0.1%阿达帕林凝胶联合治疗花斑癣
背景和目的花斑癣是一种常见的慢性浅表真菌感染,表现在青春期或青春期后湿热的温度下。局部治疗是第一线治疗,分为非特异性和特异性抗真菌药物;然而,花斑癣的治疗方法主要依赖于合成抗真菌药物,尤其是酮康唑。然而,由于这种疾病的频繁复发,以及唑类药物的广泛应用,出现了耐药性菌株,导致治疗失败率越来越高。维甲酸乳膏对花斑癣也很有效。特别是阿达帕林凝胶,与其他局部类视黄醇产品相比,它的刺激性较小,而且起效快。因此,我们旨在评估2%酮康唑乳膏和0.01%阿达帕林凝胶联合治疗花斑癣的疗效和安全性。患者和方法将100例患者平均分为两组:第一组患者外用2%酮康唑乳膏和0.1%阿达帕林凝胶,每日1次,疗程2周。第2组患者局部应用2%酮康唑乳膏治疗,总持续时间为2周。结果联合用药组疗效明显优于单纯酮康唑组,P值为0.023。阿德帕林+酮康唑组的副作用刺激性大于酮康唑组,显著P值=0.001。结论0.1%阿达帕林凝胶与2%酮康唑乳膏联合治疗花斑癣安全、快速、有效。
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34 weeks
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