Studying the Aerodynamic Characteristics of the Macrotech and Evaluation of the Possibilities of Its Use for Dynamic Aerosol Scintigraphy

Q4 Medicine
V. Kobylyansky, T. Kudasheva, M. Berezina, T. Magomedov
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Abstract

Introduction: The leading protective mechanism of the lungs is the processes of deposition of inhaled substances and mucociliary clearance (MCC), the optimal method for studying which is dynamic radioaerosol scintigraphy. are not available on the market. The applicant in this regard for a number of characteristics is the radiopharmaceutical from albumin, produced in the Russian Federation under the brand name Macrotech (M). It is used for perfusion scintigraphy to verify primarily pulmonary embolism and its ability to study deposition of inhalants and MCC has not been studied. Purpose: To study the aerodynamic properties of M dispersion and to determine the possibilities of its use for dynamic radioaerosol scintigraphy of the lungs in order to assess the processes of deposition of inhaled substances and MCC. Material and methods: To study the aerodynamic properties of M, on which the assessment of the deposition of inhaled substances and MCC significantly depends, we studied the dispersion of its particles in different states, and studied them in shape and morphology. An ultrasonic inhaler TuR USI-50 (Germany) generated an aerosol from a suspension of M in distilled water. To study the dispersion in air, laser spectrometry was used using the Spraytec Malvern Instruments system (Great Britain). The protein content in the initial suspension and dispersible aerosol, collected in the form of a condensate, was determined using an Immulite 2000 XPi immunochemical analyzer (Siemens, USA).The shape and morphology of the particles were studied using scanning electron microscopy using. Results: The study of the aerodynamic properties of the dispersion of M indicated that its particles are involved in the dynamics of the movement of the airflow and the flight of water particles generated by the inhaler. The dispersity of the aerosol generated from the suspension M averaged about 5 μm and did not significantly depend on the concentration of the radiopharmaceutical and did not depend on the studied dispersion intensity and airflow rate set using an inhaler. The morphology of M particles was characterized by a complex shape and roughness. Conclusion: The aerodynamic characteristics of M are not optimal for studying the processes of deposition and MCC. However, a final verdict requires a direct assessment of the deposition of the inhaled radioaerosol generated from this preparation.
Macrotech的气动特性研究及其用于动态气溶胶闪烁成像的可能性评估
肺的主要保护机制是吸入物质的沉积和粘膜纤毛清除(MCC)过程,动态放射性气溶胶闪烁成像是研究这一过程的最佳方法。在市场上是买不到的。这方面的许多特征的申请人是来自白蛋白的放射性药物,在俄罗斯联邦以Macrotech (M)的品牌生产。它用于灌注显像,主要用于验证肺栓塞,其研究吸入剂沉积和MCC的能力尚未研究。目的:研究M弥散的空气动力学特性,并确定其用于肺部动态放射性气溶胶闪烁成像的可能性,以评估吸入物质和MCC的沉积过程。材料和方法:为了研究M的空气动力学特性,我们研究了其颗粒在不同状态下的分散,并对其形状和形态进行了研究,M的空气动力学特性是评估吸入物质沉积和MCC的重要依据。超声波吸入器TuR USI-50(德国)从蒸馏水中的M悬浮液中产生气溶胶。为了研究空气中的弥散,使用了Spraytec Malvern仪器系统(英国)的激光光谱法。用Immulite 2000 XPi免疫化学分析仪(Siemens, USA)测定以凝析液形式收集的初始悬浮液和分散气溶胶中的蛋白质含量。利用扫描电子显微镜对颗粒的形状和形貌进行了研究。结果:M弥散的气动特性研究表明,其颗粒参与了吸入器产生的气流运动和水颗粒飞行的动力学过程。悬浮M产生的气溶胶的分散性平均约为5 μm,与放射性药物的浓度无关,与所研究的分散强度和使用吸入器设置的气流速率无关。M颗粒的形貌具有复杂的形状和粗糙度。结论:M的气动特性并不适合研究沉积和MCC过程。然而,最终结论需要对该制剂产生的吸入放射性气溶胶的沉积进行直接评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Radiology and Radiation Safety
Medical Radiology and Radiation Safety Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.40
自引率
0.00%
发文量
72
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