Effects of cardiopulmonary bypass on liver function in patients undergoing cardiac surgery

Cardiometry Pub Date : 2023-05-04 DOI:10.18137/cardiometry.2023.27.194199

A. P. Reddy, R. Sunitha, P. Thangavel, J. Ramkumar, S. Miller

引用次数: 0

Abstract

Cardiopulmonary bypass (CPB) might have several systemic impacts on organs such as the liver. This prospective research was designed to investigate the occurrence & significance of this shift in more depth.40 patients of cardiopulmonary bypass were chosen at random for the research. After coronary artery bypass grafting, total bilirubin, direct bilirubin, Alkaline Phosphatase (ALP), SGOT, & SGPT were determined preoperatively & post operation after 24, 48 hours. The liver function tests’ (LFT) post-operative value, in relation to above factors, was compared with preoperative value using t test. The results show a statistically significant increase (p ≤ 0.05) in total bilirubin, direct bilirubin, Alkaline Phosphatase, SGOT, & SGPT on post-operative days 1 & 2 in patients who had complex surgeries & valve replacement surgeries while on CPB. Low cardiac output may be related with a transient rise in hepatic enzyme levels following surgery. Throughout the post-operative period, hepatic enzyme levels were higher in patients with longer CPB durations.

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体外循环对心脏手术患者肝功能的影响

体外循环（CPB）可能会对肝脏等器官产生多种系统性影响。这项前瞻性研究旨在调查这种转变在更多部门的发生和意义。随机选择40名体外循环患者进行研究。冠状动脉搭桥术后，术前和术后24、48小时测定总胆红素、直接胆红素、碱性磷酸酶（ALP）、SGOT和SGPT。肝功能测试（LFT）的术后价值与上述因素有关，并用t检验与术前价值进行比较。结果显示，在CPB期间进行复杂手术和瓣膜置换手术的患者，术后第1天和第2天，总胆红素、直接胆红素、碱性磷酸酶、SGOT和SGPT有统计学意义的增加（p≤0.05）。心输出量低可能与手术后肝脏酶水平的短暂升高有关。在整个术后期间，CPB持续时间较长的患者肝脏酶水平较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.