Assessment of antibody titer and side effects after third doses of COVID-19 mRNA vaccination in healthy volunteers

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Journal of Laboratory Medicine Pub Date : 2022-05-25 DOI:10.1515/labmed-2022-0057

Rikei Kozakai, Susumu Suzuki, Kana Fukami, Kuniko Hoshi, Yoshihiko Izumi, Shin-ichiro Takahashi

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引用次数: 2

Abstract

Abstract Objectives Third dose of SARS-CoV-2 vaccination was started from December 1, 2021 in Japan. However, data on the precise analysis of the side effects after third vaccination, remain scarce. Here, we examined the side effects and the levels of SARS-CoV-2 IgG antibody in healthy volunteers who underwent BNT162b2 vaccination. Methods Forty-one healthy volunteers were assessed for the side effects of the vaccination for the third dose, and samples were used for the measurement of SARS-CoV-2 IgG antibody with chemiluminescent assays against the Receptor Binding Domain (RBD) of the virus. Results We analyzed the humoral responses and found that the IgG levels showed clear declining trends with age. Commonly reported side effects in the participants after the third dose were similar to those in second dose, such as, generalized weakness/fatigue (65.9%), headache (58.5%), and sore arm/pain (87.8%). The frequency of the fever was slightly less (39.0%), compared to the second dose (57.5%), but localized symptoms, such as itching (14.6%) and lymphadenopathy (14.6%) were not negligible, which were not seen at the second dose. The number of side effects were tended to be decreased with age. Conclusions The production of IgG after the third doses of BNT162b2 vaccination decreases age-dependently. The number of side effects were tended to be decreased with age. The high frequencies of generalized weakness/fatigue, fever, and sore arm/pain were not negligible, after the third dose.

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健康志愿者第三次接种COVID-19 mRNA疫苗后抗体滴度和副作用的评估

目的日本于2021年12月1日开始第三次接种SARS-CoV-2疫苗。然而，关于第三次疫苗接种后副作用的精确分析数据仍然很少。在这里，我们检查了接受BNT162b2疫苗接种的健康志愿者的副作用和SARS-CoV-2 IgG抗体水平。方法对41名健康志愿者进行第三次疫苗接种副反应评估，并用化学发光法检测SARS-CoV-2抗体受体结合域(RBD)。结果我们分析了体液反应，发现IgG水平随年龄的增长有明显的下降趋势。第三次给药后常见的副作用与第二次给药相似，如全身无力/疲劳(65.9%)、头痛(58.5%)和手臂酸痛/疼痛(87.8%)。与第二次剂量(57.5%)相比，发热的频率略低(39.0%)，但局部症状，如瘙痒(14.6%)和淋巴结病(14.6%)不容忽视，这些在第二次剂量时没有出现。副作用的数量随着年龄的增长而减少。结论第三次接种BNT162b2疫苗后IgG的产生呈年龄依赖性降低。副作用的数量随着年龄的增长而减少。在第三次剂量后，广泛性虚弱/疲劳、发热和手臂酸痛/疼痛的高频率是不可忽略的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Laboratory Medicine Mathematics-Discrete Mathematics and Combinatorics

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Laboratory Medicine (JLM) is a bi-monthly published journal that reports on the latest developments in laboratory medicine. Particular focus is placed on the diagnostic aspects of the clinical laboratory, although technical, regulatory, and educational topics are equally covered. The Journal specializes in the publication of high-standard, competent and timely review articles on clinical, methodological and pathogenic aspects of modern laboratory diagnostics. These reviews are critically reviewed by expert reviewers and JLM’s Associate Editors who are specialists in the various subdisciplines of laboratory medicine. In addition, JLM publishes original research articles, case reports, point/counterpoint articles and letters to the editor, all of which are peer reviewed by at least two experts in the field.