Evaluation of hemodialysis adequacy using urea reduction rate and related factors in Iranian patients’ undergoing hemodialysis in Guilan, Iran

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2023-02-18 DOI:10.34172/jrip.2023.32132

M. Yaseri, H. S. Fayazi, Seyyedeh Sahereh Mortazavi Khatibani, Azin Hajipoor

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引用次数: 0

Abstract

Introduction: Dialysis quality is an important factor in reducing inability and mortality in chronic kidney failure patients and can enhance their life quality and social activity. Objectives: The aim of this investigation was to examine the efficacy of dialysis based on urea reduction rate (URR) and the associated factors in hemodialysis patients due to the lack of clarity on the adequacy of dialysis. Patients and Methods: This multicenter cross-sectional study was conducted on 344 hemodialysis patients over 18 years and referred to seven dialysis centers in Guilan, Iran. The adequacy of dialysis was obtained using URR (>65%) criteria. Results: The mean URR of studied patients was 63 ±10.4%. The desirable dialysis adequacy was reached in 45.9% of the patients. There was a significant negative association between URR and BMI (r= -0.155, P =0.005). Patients who had normal calcium levels had significantly higher URR adequacy than patients with abnormal calcium levels ( P <0.001). The URR criterion was contrariwise associated to blood pressure before and after dialysis ( P <0.05). There was a significant association between the length of the time, patients underwent dialysis (in year) and URR (R=125, P =0.023). Conclusion: This study indicated that URR is a desirable criterion for dialysis adequacy, which was associated with blood pressure, serum calcium level and body mass index (BMI). These findings suggest providing treatment strategies based on these findings to enhance the effect of dialysis adequacy.

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伊朗桂兰地区血液透析患者尿素还原率及相关因素评价血液透析充分性

引言：透析质量是降低慢性肾衰竭患者无力和死亡率的重要因素，可以提高他们的生活质量和社会活动。目的：本研究的目的是检查基于尿素还原率（URR）的透析的疗效，以及由于透析的充分性不明确而导致血液透析患者的相关因素。患者和方法：这项多中心横断面研究对344名18年以上的血液透析患者进行，并将其转诊至伊朗吉兰的七个透析中心。使用URR（>65%）标准获得透析的充分性。结果：研究患者的平均URR为63±10.4%，45.9%的患者达到了理想的透析充分性。URR与BMI呈显著负相关（r=-0.155，P=0.005）。钙水平正常的患者的URR充分性显著高于钙水平异常的患者（P<0.001）。URR标准与透析前后的血压呈相反关系（P<0.05），患者接受了透析（年）和URR（R=125，P=0.023）。结论：URR是一个理想的透析充分性标准，与血压、血清钙水平和体重指数（BMI）有关。这些发现建议提供基于这些发现的治疗策略，以提高透析充分性的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.