Complaints of a patient — as predictors of adverse outcomes in tuberculosis with HIV infection

Abstract

Objective. To detect patient’s complaints on admission to the hospital, statistically important with adverse outcome in tuberculosis with HIV infection, most sensitivity and specificity.Materials and methods. 363 patients were examined with tuberculosis and HIV infection. The first group included 59 (16,3%) patients with adverse disease outcome, the second group contained 304 patients (83,7%) with favorable outcome. Methods: clinical, laboratory, microbiological, statistical: analysis of pairwise contingency tables by Pearson’s criterion, Mann-Whitney test on quantitative characteristics, logistic regression.Results and discussion. The highest odds ratio of sensitivity and specificity among HIV and tuberculosis patient’s complaints, highly probable on risk of adverse outcome (р<0,0001), has fever — 26,8, 93,2% and 66,1%, loose stools — 25,4, 40,7% and 97,4%, weight loss — 18,8, 72,9% and 87,5%, loss of appetite — 17,0, 69,5% and 88,2%, shortness of breath — 15,6, 79,7% and 79,9%, weakness — 8,7, 91,5% and 44,7%, headache — 7,4, 49,2% and 88,5% accordingly. Thus, in the absence of other complaints the risk of adverse outcome in a patient with HIV and tuberculosis, compared to a patient with no such complaints increases for fever 26,8 times, for loose stools — 25,4 times, for weight loss — 18,8 times, for loss of appetite — 17,0 times, for shortness of breath —15,6 times, for weakness — 8,7 times, for headache — 7,4 times.