Spatial modeling for correlated cancers using bivariate directed graphs

Leiwen Gao, Sudipto Banerjee, A. Datta
{"title":"Spatial modeling for correlated cancers using bivariate directed graphs","authors":"Leiwen Gao, Sudipto Banerjee, A. Datta","doi":"10.21037/ACE-19-41","DOIUrl":null,"url":null,"abstract":"Disease maps are an important tool in cancer epidemiology used for the analysis of geographical variations in disease rates and the investigation of environmental risk factors underlying spatial patterns. Cancer maps help epidemiologists highlight geographic areas with high and low prevalence, incidence, or mortality rates of cancers, and the variability of such rates over a spatial domain. When more than one cancer is of interest, the models must also capture the inherent or endemic association between the diseases in addition to the spatial association. This article develops interpretable and easily implementable spatial autocorrelation models for two or more cancers. The article builds upon recent developments in univariate disease mapping that have shown the use of mathematical structures such as directed acyclic graphs to capture spatial association for a single cancer, estimating inherent or endemic association for two cancers in addition to the association over space (clustering) for each of the cancers. The method builds a Bayesian hierarchical model where the spatial effects are introduced as latent random effects for each cancer. We analyze the relationship between incidence rates of esophagus and lung cancer extracted from the Surveillance, Epidemiology, and End Results (SEER) Program. Our analysis shows statistically significant association between the county-wise incidence rates of lung and esophagus cancer across California. The bivariate directed acyclic graphical model performs better than competing bivariate spatial models in the existing literature.","PeriodicalId":92868,"journal":{"name":"Annals of cancer epidemiology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of cancer epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21037/ACE-19-41","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

Abstract

Disease maps are an important tool in cancer epidemiology used for the analysis of geographical variations in disease rates and the investigation of environmental risk factors underlying spatial patterns. Cancer maps help epidemiologists highlight geographic areas with high and low prevalence, incidence, or mortality rates of cancers, and the variability of such rates over a spatial domain. When more than one cancer is of interest, the models must also capture the inherent or endemic association between the diseases in addition to the spatial association. This article develops interpretable and easily implementable spatial autocorrelation models for two or more cancers. The article builds upon recent developments in univariate disease mapping that have shown the use of mathematical structures such as directed acyclic graphs to capture spatial association for a single cancer, estimating inherent or endemic association for two cancers in addition to the association over space (clustering) for each of the cancers. The method builds a Bayesian hierarchical model where the spatial effects are introduced as latent random effects for each cancer. We analyze the relationship between incidence rates of esophagus and lung cancer extracted from the Surveillance, Epidemiology, and End Results (SEER) Program. Our analysis shows statistically significant association between the county-wise incidence rates of lung and esophagus cancer across California. The bivariate directed acyclic graphical model performs better than competing bivariate spatial models in the existing literature.
使用二元有向图的相关癌症空间建模
疾病地图是癌症流行病学中的一个重要工具,用于分析疾病发病率的地理变化和调查潜在空间模式的环境风险因素。癌症地图有助于流行病学家突出癌症患病率、发病率或死亡率高和低的地理区域,以及这些发病率在空间域上的可变性。当不止一种癌症感兴趣时,除了空间关联之外,模型还必须捕捉疾病之间固有的或地方性的关联。本文为两种或多种癌症开发了可解释且易于实现的空间自相关模型。这篇文章建立在单变量疾病映射的最新发展基础上,该研究表明,使用数学结构(如有向无环图)来捕捉单个癌症的空间关联,除了每种癌症的空间关联(聚类)外,还估计两种癌症的固有或地方关联。该方法建立了贝叶斯分层模型,其中空间效应被引入为每个癌症的潜在随机效应。我们分析了从监测、流行病学和最终结果(SEER)计划中提取的食管和肺癌癌症发病率之间的关系。我们的分析显示,加利福尼亚州肺和食管癌症的县发病率之间存在显著的统计相关性。在现有文献中,双变量有向无环图形模型比竞争的双变量空间模型表现更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信