COVID-19 Yoğun Bakım Hastalarında Serum Ürik Asit Düzeyinin Solunum Yetmezliğinin Ciddiyeti ve Mortalite Üzerine Etkisi

Abstract

Objective: Routine laboratory parameters such as C-reactive protein (CRP), procalcitonin, ferritin, d-dimer are used to estimate the clinical severity and mortality of Coronavirus disease 2019 (COVID-19). Because of the limited specificity of these parameters and their variability between patients, more specific parameters are needed. It is thought that there may be a relationship between uric acid levels and the severity and mortality of COVID-19. In this study, we aimed to retrospectively investigate the relationship between daily serum uric acid measurements in the first 10 days of follow-up in the intensive care unit (ICU) and the need for invasive mechanical ventilation (IMV) and mortality. Methods: With the approval of the ethics committee, 151 eligible patients were screened through the ICU patient records and routine laboratory data on the computer. Serum uric acid measurements, demographic and clinical characteristics, IMV needs and mortality rates at the first admission to the hospital and in the first 10 days in the ICU were recorded retrospectively. Results: In the analysis, rate of IMV was 60.3% and mortality was 53.6%. No significant correlation was found between the uric acid levels measured at the time of first hospitalization and in the ICU follow-up and the need for IMV. In the comparison between deceased and survived patient groups; the uric acid levels were found to be higher on the 3rd and 4th days of the ICU in the deceased group than in the survivors (p=0.023, p=0.037, respectively). Conclusion: The increase in uric acid levels on the 3rd and 4th days in COVID-19 patients requiring ICU admission seems to be significant in the estimation of mortality. Serum uric acid level can be a useful parameter in determining the prognosis in the ICU follow-up of this group patients. Keywords: Intensive care, uric acid, COVID 19, mortality, mechanical ventilation