Peculiarities of some candidate gene polymorphisms in Parkinson’s disease

Abstract

Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder among elderly individuals, after Alzheimer’s disease. This complex disorder manifests with multiple motor and non-motor features and is often diagnosed only after the onset of significant pathological symptoms. Based on the presumption that epigenetic mechanisms are involved in neurodevelopment and synaptic transmission, it is hypothesized that epigenetic alterations are closely connected to the development of PD. Several studies have reported that genetic risk factors are involved in PD susceptibilities. These factors play a prominent role in the predisposition and development of PD and may be closely linked to different metabolic pathways. In this review, we revise associations between single nucleotide polymorphisms (SNPs) and PD pathogenesis.