A Polysomnographic and Cluster Analysis of Periodic Limb Movements in Sleep of Restless Legs Syndrome Patients with Psychiatric Conditions

IF 1.2 Q4 PSYCHIATRY
A. Walters, J. Brunelin, S. Catoire, M. Suaud-Chagny, K. Spruyt
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引用次数: 0

Abstract

Only survey studies have linked specific individual psychiatric disorders such as anxiety, depression and schizophrenia to Restless Legs Syndrome (RLS), Periodic Limb Movements in Sleep (PLMS) or both. We therefore aim to polysomnographically characterize sleep in a sample of physician-based, newly diagnosed cases of RLS with various ICD-10 psychiatric diagnoses. Retrospective analysis of data from a convenience sample of psychiatric patients (n = 43) per standard clinical sleep disorder cut-offs was conducted. Next, a cluster analysis was performed on the sleep data, taking into account the psychiatric diagnosis, comorbid non-psychiatric somatic problems and medication. We found that 37.2% of our sample showed clinically significant PLMS ≥ 15 and 76.5% exhibited an apnea hypopnea index (AHI) ≥ 5. Sleep structure was unaltered apart from the PLMS-related parameters. Two clusters were statistically identified: Cluster 1 primarily representing recurrent major depressive issues and Cluster 2 representing present but not predominant mood symptomatology as well as mixed disorders with personality problems. The known confounders were controlled. A PLMS index ≥ 15 was differentially distributed among the two clusters with Cluster 1: 10 out of 17 with PLMS index ≥ 15; Cluster 2: 1 out of 16 with PLMS index ≥15; whilst AHI was not different. Patients in Cluster 1 have a higher rate of periodic leg movements than patients in Cluster 2. This suggests that the high association with PLMS is primarily driven by affective disorders. Our findings warrant questioning of RLS symptomatology in patients with psychiatric conditions.
伴有精神疾病的不宁腿综合征患者睡眠中周期性肢体运动的多导睡眠图和聚类分析
只有调查研究将焦虑、抑郁和精神分裂症等特定的个体精神疾病与不宁腿综合征(RLS)、睡眠中的周期性肢体运动(PLMS)或两者联系起来。因此,我们的目标是在医生为基础的样本中,多导睡眠描记仪表征睡眠,新诊断的RLS病例具有各种ICD-10精神病学诊断。根据标准临床睡眠障碍截止时间对精神病患者(n = 43)的方便样本数据进行回顾性分析。接下来,对睡眠数据进行聚类分析,考虑到精神诊断、共病的非精神躯体问题和药物。我们发现37.2%的患者PLMS≥15,76.5%的患者呼吸暂停低通气指数(AHI)≥5。除了plms相关参数外,睡眠结构没有改变。统计上确定了两类:第一类主要代表复发性重度抑郁问题,第二类代表目前但不主要的情绪症状,以及伴有人格问题的混合障碍。已知的混杂因素得到了控制。PLMS指数≥15的集群间存在差异,集群1:17个集群中有10个集群PLMS指数≥15;聚类2:PLMS指数≥15的16个国家中有1个;而AHI没有什么不同。第一类患者的周期性腿部运动率高于第二类患者。这表明与PLMS的高度关联主要是由情感性障碍驱动的。我们的研究结果对精神疾病患者的RLS症状提出了质疑。
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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
0
审稿时长
11 weeks
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