The effect of hyoscine butyl bromide in shortening the duration of first stage of labor: A single-blind randomized control study

R. Ibrahim, E. Nwobodo, K. Tunau, A. Burodo, B. Sulaiman, J. Garba, A. Saidu
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引用次数: 2

Abstract

Background: Active management of labor reduces the number of prolonged labor and the duration of labor without having any adverse effects on the mother and the fetus. Intervention with drugs is among the options used for active management of labor. This includes use of analgesics, oxytocics, prostaglandins derivatives, and smooth muscle relaxants. The objectives of the study were to determine whether hyoscine N butyl bromide (HNBB) shortens the first stage of labor in term pregnancies, to compare the mean duration of labor between primigravidae and multigravidae in HBB group, to compare the maternal and fetal outcome between HBB and control group, and also to determine the side effects of HBB in parturients. Materials and Methods: The study was a single-blind randomized control study carried out in Usmanu Danfodiyo University Teaching Hospital (UDUTH) over 4-month period. A total of 204 pregnant women at term in spontaneous labor who presented in active phase of labor at UDUTH and have met the inclusion criteria were recruited and randomized into 102 women as case group and 102 women as control. The women in the case group received 40 mg (2 mls) of HBB, while those in the control group received 2 mls of normal saline. Data entry and analysis was done with IBM SPSS version 20. The duration and outcome was monitored. Results: The mean duration of labor in the first stage among the case group was 5:44 ± 2:11, while it was 6:52 ± 2:11 among the control group representing a decrease of 16.5%. This was statistically significant (P < 0.05). There was no difference in the duration of the second and third stages of labor among the two groups. There was no difference in the maternal and neonatal outcome among the two groups. Vomiting was the only maternal side effect that was statistically significant among the HBB group. Conclusion: HBB reduced the duration of first stage of labor in both primigravid and multigravid women without adverse maternal and neonatal complications. It is recommended that HBB to be given to women in active phase of labor to reduce the incidence of prolonged labor.
丁溴海莨菪碱缩短第一产程持续时间的效果:一项单盲随机对照研究
背景:积极管理产程可减少产程延长次数和产程持续时间,对母婴无不良影响。药物干预是积极管理分娩的选择之一。这包括使用镇痛药、催产素、前列腺素衍生物和平滑肌松弛剂。本研究的目的是确定海莨菪碱N丁基溴化剂(HNBB)是否缩短足月妊娠的第一产程,比较HBB组初产妇和多胎产妇的平均产程,比较HBB组与对照组的母胎结局,以及确定HBB对产妇的不良反应。材料与方法:本研究为单盲随机对照研究,在乌斯马努丹佛迪约大学教学医院(UDUTH)进行为期4个月的研究。本研究共招募了204例在UDUTH产程处于活跃期的自然分娩足月孕妇,符合纳入标准,随机分为102例作为病例组,102例作为对照组。病例组的妇女接受40毫克(2毫升)的HBB,而对照组的妇女接受2毫升生理盐水。数据输入和分析使用IBM SPSS version 20完成。监测治疗的持续时间和结果。结果:病例组第一产程平均为5:44±2:11,对照组为6:52±2:11,缩短了16.5%。差异有统计学意义(P < 0.05)。两组第二、三产程的持续时间无差异。两组的产妇和新生儿结局没有差异。呕吐是HBB组中唯一有统计学意义的产妇副作用。结论:HBB减少了原孕和多孕妇女第一产程的持续时间,没有不良的产妇和新生儿并发症。建议在产程活跃期给予HBB,以减少延长产程的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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