High incidence of prolonged rectal bleeding and advanced stage cancer in early-onset colorectal cancer patients

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2020-09-01 DOI:10.2217/crc-2020-0012

G. Sandhu, R. Anders, P. Blatchford, A. Walde, A. Leal, G. King, S. Leong, S. L. Davis, W. Purcell, K. Goodman, T. Schefter, Michelle L. Cowan, W. Herter, C. Meguid, Reed Weiss, Megan D. Marsh, M. Brown, J. Vogel, E. Birnbaum, S. Ahrendt, A. Gleisner, R. Schulick, M. Chiaro, M. McCarter, Swati G. Patel, W. Messersmith, C. Lieu

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引用次数: 2

Abstract

Background: We examined characteristics of early-onset colorectal cancer (CRC) patients to identified factors, which may lead to earlier diagnosis. Materials & methods: This is a retrospective study with inclusion criteria: CRC diagnosed between 2012 and 2018 and age at diagnosis <50 years. Results: A total of 209 patients were included (mean age 41.8 years). Of those patients 42.5% had rectal cancer and 37.8% were stage IV at initial diagnosis. Of patients with data available for rectal bleeding history (n = 173), 50.8% presented with rectal bleeding and median time from onset of bleeding to diagnosis was 180 days (interquartile range 60–365), with longer duration noted in advanced cancer. Conclusion: Prolonged rectal bleeding history was noted in a significant proportion of early-onset CRC patients, with longer duration of rectal bleeding noted in stage IV patients. Patients and primary care physicians should be made aware of this finding in order to facilitate timely referral for diagnostic workup.

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早发性结直肠癌患者长期直肠出血及晚期癌症的高发

背景：我们检查了早发性癌症（CRC）患者的特征，以确定可能导致早期诊断的因素。材料和方法：这是一项具有纳入标准的回顾性研究：2012年至2018年间诊断为CRC，诊断时年龄<50岁。结果：共有209例患者（平均年龄41.8岁），其中42.5%的患者为癌症，37.8%的患者在初诊时为IV期。在有直肠出血史数据的患者中（n=173），50.8%的患者出现直肠出血，从出血开始到诊断的中位时间为180天（四分位数间距60–365），晚期癌症持续时间更长。结论：早发性CRC患者有较长的直肠出血史，IV期患者直肠出血持续时间较长。患者和初级保健医生应该意识到这一发现，以便及时转诊进行诊断检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.