A. Janati, Y. Ouzidan, Y. Rodi, F. O. Chahdi, M. Chraibi, K. F. Benbrahim, I. Alaoui, A. E. Hakmaoui, M. Safi, M. Akssira, E. Essassi
{"title":"Synthesis and antimicrobial activity of some quinoxaline derivatives","authors":"A. Janati, Y. Ouzidan, Y. Rodi, F. O. Chahdi, M. Chraibi, K. F. Benbrahim, I. Alaoui, A. E. Hakmaoui, M. Safi, M. Akssira, E. Essassi","doi":"10.48317/IMIST.PRSM/MORJCHEM-V9I2.25855","DOIUrl":null,"url":null,"abstract":"Some new structural motifs containing the quinoxaline nucleus have been synthesized and examined for their pharmacological properties. In this study, 6-chloroquinoxaline-2,3(1H, 4H)-dione and 6 nitroquinoxaline-2,3(1H, 4H)-dione were synthesized as basic nuclei for the preparation of the new quinoxaline-2,3-diones by alkylation reactions under the conditions of phase transfer catalysis. The products were characterized by spectroscopic methods 1 H and 13 C NMR. Then, the synthesized products were tested for their antibacterial effects against two bacterial strains. The values of minimum inhibitory concentrations (MIC) vary according to the nature of the alkyl bonded to the quinoxaline nucleus.","PeriodicalId":18768,"journal":{"name":"Moroccan Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moroccan Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.48317/IMIST.PRSM/MORJCHEM-V9I2.25855","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 4
Abstract
Some new structural motifs containing the quinoxaline nucleus have been synthesized and examined for their pharmacological properties. In this study, 6-chloroquinoxaline-2,3(1H, 4H)-dione and 6 nitroquinoxaline-2,3(1H, 4H)-dione were synthesized as basic nuclei for the preparation of the new quinoxaline-2,3-diones by alkylation reactions under the conditions of phase transfer catalysis. The products were characterized by spectroscopic methods 1 H and 13 C NMR. Then, the synthesized products were tested for their antibacterial effects against two bacterial strains. The values of minimum inhibitory concentrations (MIC) vary according to the nature of the alkyl bonded to the quinoxaline nucleus.
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