Human leukocyte antigens (HLA) association with myasthenia gravis (MG) and its myasthenia manifestations in Algerian patients

IF 0.8 Q4 GENETICS & HEREDITY

Meta Gene Pub Date : 2021-09-01 DOI:10.1016/j.mgene.2021.100937

Bouchtout Mohamed Nadji , Meçabih Fethi , Mihoubi Esma , Boukadir Chahrazad , Attal Elias , Daoudi Smail , Touil-Boukoffa Chafia , Raache Rachida , Attal Nabila

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引用次数: 0

Abstract

Background

Myasthenia gravis (MG) is an autoimmune disease with a well-established involvement of genetic factors.

Aim

this study was to assess the human leukocyte antigens (HLA) genes association with myasthenia gravis and its myasthenic manifestations.

Methods

We performed a case-control study where twenty eight patients and one hundred and nine healthy subjects were included. A subgroup of generalized and acetylcholine receptor antibodies positive myasthenia gravis was examined for myasthenic manifestations associations. HLA genotyping was performed by polymerase chain reaction- sequence specific oligonucleotide (PCR-SSO) method.

Results

On one hand, HLA A*30 and DRB1*04 alleles were more frequent among patients with myasthenia gravis whereas A*02 and B*49 were less frequent (p < 0.05). On the other hand, B*08 was positively associated with limb muscles weakness and negatively association with dysphagia while B*44 and DRB1*03 were both positively associate with cervical muscles weakness (p < 0.05).

Conclusion

Our results suggest the association of various HLA alleles with myasthenia gravis and some of its myasthenic manifestations. However, further studies are required support these findings and clarify the underlying mechanisms.

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人白细胞抗原(HLA)与阿尔及利亚重症肌无力(MG)及其重症肌无力表现的关系

背景重症肌无力(MG)是一种与遗传因素相关的自身免疫性疾病。本研究旨在探讨人白细胞抗原(HLA)基因与重症肌无力及其症状的相关性。方法采用病例对照研究，纳入28例患者和109名健康受试者。重症肌无力亚群的广泛性和乙酰胆碱受体抗体阳性检查重症肌无力的表现关联。HLA基因分型采用聚合酶链反应-序列特异性寡核苷酸(PCR-SSO)法。结果重症肌无力患者HLA A*30、DRB1*04等位基因较多，A*02、B*49等位基因较少(p <0.05)。另一方面，B*08与肢体肌无力呈正相关，与吞咽困难呈负相关，而B*44和DRB1*03与颈肌无力均呈正相关(p <0.05)。结论多种HLA等位基因与重症肌无力及其部分症状有关。然而，需要进一步的研究来支持这些发现并阐明潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.