Selective and sensitive GC-MS analysis of carcinogenic N-nitrosodimethylamine in pharmaceuticals using a magnetic coconut carbon composite as a solid-phase extraction sorbent

IF 2.8 3区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Taibah University for Science Pub Date : 2023-09-06 DOI:10.1080/16583655.2023.2254352

Hazim M Ali, I. Alsohaimi, Mohammad Rizwan Khan, Ibrahim A. Naguib, Rosa Busquets, P. Alam, Bayan E Ainousah, Mohammed Gamal

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Abstract

The aim of the present research was to develop a magnetic coconut carbon composite (Fe2O3/Fe3O4@CNC) as a solid-phase extraction (SPE) sorbent for the analysis of carcinogenic N-nitrosodimethylamine (NDMA) in pharmaceuticals. Coconut composites modified with Fe2O3 and Fe3O4 were prepared and applied as SPE sorbent for the extraction of NDMA in pharmaceuticals. The sorbent was characterized with X-Ray, infrared spectroscopy and nitrogen porosimetry. The best ions for the Gas Chromatography-Mass Spectrometry with Selected Ion Monitoring (GC-MS/SIM) analysis were m/z 74 and 42 for NDMA, and m/z 80 and 46 for NDMA-d6 internal standard. System has offered great method performance in terms of sensitivity limit of quantitation (LOQ) 16 ng kg−1. The developed sorbent has enhanced the sensitivity and speed of analysis. The developed method was applied to authenticate the presence of NDMA in various pharmaceutical samples. Among the analyzed samples, NDMA impurities were relatively identified at high amounts in nizatidine samples. Highlights NDMA was verified in ranitidine, metformin and nizatidine Fe2O3/Fe3O4@CNC composite was used for NDMA identification without pretreatment SPE sorbent enhance sensitivity, reduce analysis time, sustain accuracy & precision High level of NDMA impurity were found in nizatidine pharmaceuticals. GRAPHICAL ABSTRACT

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来源期刊

Journal of Taibah University for Science MULTIDISCIPLINARY SCIENCES-

CiteScore

6.60

自引率

6.10%

发文量

102

审稿时长

19 weeks

期刊介绍： Journal of Taibah University for Science (JTUSCI) is an international scientific journal for the basic sciences. This journal is produced and published by Taibah University, Madinah, Kingdom of Saudi Arabia. The scope of the journal is to publish peer reviewed research papers, short communications, reviews and comments as well as the scientific conference proceedings in a special issue. The emphasis is on biology, geology, chemistry, environmental control, mathematics and statistics, nanotechnology, physics, and related fields of study. The JTUSCI now quarterly publishes four issues (Jan, Apr, Jul and Oct) per year. Submission to the Journal is based on the understanding that the article has not been previously published in any other form and is not considered for publication elsewhere.