High doses of cobalt inhibited hair follicle development in Rex Rabbits

IF 0.8 4区农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE

World Rabbit Science Pub Date : 2019-12-23 DOI:10.4995/wrs.2019.12038

L. Liu, Q. Gao, C. Wang, Z. Fu, K. Wang, F. Li

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引用次数: 2

Abstract

An experiment was conducted to investigate the effect of cobalt supplementation on hair follicle development in rabbits. Rex rabbits (30-d-old, n=180) were divided randomly into five equal treatment groups: rabbits fed a basal diet (control, measured cobalt content of 0.27 mg/kg) or rabbits fed a basal diet with an additional 0.1, 0.4, 1.6 or 6.4 mg/kg cobalt (in the form of cobalt sulfate) supplementation (measured cobalt contents of 0.35, 0.60, 1.83 and 6.62 mg/kg, respectively). Treatment with 6.4 mg/kg cobalt significantly decreased hair follicle density ( P 0.05). The addition of dietary cobalt at the highest level examined (6.4 mg/kg) significantly increased the gene expression of bone morphogenetic protein (BMP) 2 and BMP4 in skin tissue ( P 0.05). Compared with their levels in the control group, dietary cobalt treatment significantly suppressed the protein levels of p-mechanistic target of rapamycin (mTOR) and p-ribosomal protein S6 protein kinase ( P 0.05). In conclusion, cobalt at the highest concentration examined inhibited hair follicle development, which may have involved the mTOR-BMP signalling pathway.

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高剂量钴抑制獭兔毛囊发育

本试验旨在研究饲粮中添加钴对家兔毛囊发育的影响。将30日龄獭兔(n=180)随机分为5个处理组，分别饲喂基础饲粮(对照组，测量钴含量为0.27 mg/kg)和在基础饲粮中添加0.1、0.4、1.6或6.4 mg/kg钴(以硫酸钴的形式)(测量钴含量分别为0.35、0.60、1.83和6.62 mg/kg)。6.4 mg/kg钴处理显著降低毛囊密度(p0.05)。饲粮中添加最高水平钴(6.4 mg/kg)显著提高了皮肤组织中骨形态发生蛋白(BMP) 2和BMP4基因的表达(P < 0.05)。与对照组相比，饲粮钴处理显著抑制了雷帕霉素对机制靶蛋白(mTOR)和对核糖体蛋白S6蛋白激酶的蛋白水平(P 0.05)。综上所述，最高浓度的钴抑制了毛囊的发育，这可能与mTOR-BMP信号通路有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Rabbit Science 农林科学-奶制品与动物科学

CiteScore

1.70

自引率

25.00%

发文量

审稿时长

>36 weeks

期刊介绍： World Rabbit Science is the official journal of the World Rabbit Science Association (WRSA). One of the main objectives of the WRSA is to encourage communication and collaboration among individuals and organisations associated with rabbit production and rabbit science in general. Subject areas include breeding, genetics, production, management, environment, health, nutrition, physiology, reproduction, behaviour, welfare, immunology, molecular biology, metabolism, processing and products. World Rabbit Science is the only international peer-reviewed journal included in the ISI Thomson list dedicated to publish original research in the field of rabbit science. Papers or reviews of the literature submitted to World Rabbit Science must not have been published previously in an international refereed scientific journal. Previous presentations at a scientific meeting, field day reports or similar documents can be published in World Rabbit Science, but they will be also subjected to the peer-review process. World Rabbit Science will publish papers of international relevance including original research articles, descriptions of novel techniques, contemporaryreviews and meta-analyses. Short communications will only accepted in special cases where, in the Editor''s judgement, the contents are exceptionally exciting, novel or timely. Proceedings of rabbit scientific meetings and conference reports will be considered for special issues. World Rabbit Science is published in English four times a year in a single volume. Authors may publish in World Rabbit Science regardless of the membership in the World Rabbit Science Association, even if joining the WRSA is encouraged. Views expressed in papers published in World Rabbit Science represent the opinion of the author(s) and do not necessarily reflect the official policy of the WRSA or the Editor-in-Chief.