Exploring the interactions between buffers and cyclodextrin complexes—formation of regular inclusion or atypical non-inclusion complexes

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-10-15 DOI:10.1007/s10847-021-01111-4

Lisa Samuelsen, Rene Holm, Christian Schönbeck

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引用次数: 2

Abstract

The aim of this study was for the first time to determine the effect of 11 buffers on a γ-cyclodextrin complex, and use these and previous reported data to systematically explore the effect of buffers on different cyclodextrin complexes, considering differences in cavity size and exterior between the cyclodextrins. The effect of 11 buffers on the binding between γ-cyclodextrin and the bile salt taurochenodeoxycholate was determined using isothermal titration calorimetry, and the stability constant of the complex ranged from 6.1 × 10⁴ to 9.0 × 10⁴ M⁻¹, depending on the buffer species. Three buffers (citric, maleic and 2-morpholinoethane-sulfonic acid) decreased the stability constant of the complex compared to the stability in water, though to a degree that has limited practical relevance. As for other cyclodextrin complexes, the stability constant depended on the buffer species present in solution. The analysis showed that the size of the cyclodextrin cavity, rather than the exterior, was paramount for the effect of carboxylic acid buffers, suggesting formation of regular inclusion complexes between carboxylic acid buffers and cyclodextrins.

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探讨缓冲液与环糊精配合物之间的相互作用——形成规则包合物或非典型包合物

本研究的目的是首次确定11种缓冲液对γ-环糊精配合物的影响，并利用这些数据和先前报道的数据系统地探讨缓冲液对不同环糊精配合物的影响，考虑环糊精之间腔大小和外观的差异。采用等温滴定量热法测定了11种缓冲剂对γ-环糊精与胆盐牛磺代脱氧胆酸盐结合的影响，其稳定常数随缓冲剂种类的不同而变化，范围为6.1 × 104 ~ 9.0 × 104 M−1。与在水中的稳定性相比，三种缓冲液(柠檬酸、马来酸和2-morpholinoethane-磺酸)降低了配合物的稳定常数，尽管在一定程度上具有有限的实际相关性。对于其他环糊精配合物，其稳定性常数与溶液中存在的缓冲物质有关。分析表明，羧酸缓冲液与环糊精之间形成了规则的包合物，影响环糊精作用的主要因素是环糊精腔的大小，而不是表面。

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来源期刊

Journal of Inclusion Phenomena and Macrocyclic Chemistry Agricultural and Biological Sciences-Food Science

CiteScore

4.10

自引率

8.70%

发文量

期刊介绍： The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.