CURRENT THERAPEUTIC STRATEGIES AND CHALLENGES IN NSCLC TREATMENT: A COMPREHENSIVE REVIEW.

Q3 Medicine

Experimental oncology Pub Date : 2022-05-01 DOI:10.32471/exp-oncology.2312-8852.vol-44-no-1.17411

M. Kumar, A. Sarkar

引用次数: 6

Abstract

Non-small cell lung cancer (NSCLC) is one of the most lethal malignancies accountings for nearly 80% of all lung cancer cases diagnosed and causing over one million deaths annually worldwide. The discovery of molecular alterations including driver mutations and gene fusions has led to innovation of numerous targeted therapies, which certainly provided an edge over the classical chemotherapeutic treatment regimens and improved survival of the patients. Despite all the breakthrough innovations, the five-year survival statistics has not improved the way it was expected, pointing the challenges and limitations of currently approved diagnostic methods and therapies. This review summarizes various innovative therapies, treatment regimens developed over the last two decades for NSCLC treatment and the current challenges and limitations in the NSCLC treatment landscape.

查看原文本刊更多论文

当前非小细胞肺癌治疗的策略和挑战:全面回顾。

非小细胞癌症（NSCLC）是最致命的恶性肿瘤之一，占全世界诊断的癌症病例的近80%，每年造成100多万人死亡。包括驱动突变和基因融合在内的分子改变的发现导致了许多靶向治疗的创新，这无疑为传统的化疗治疗方案提供了优势，并提高了患者的生存率。尽管有所有突破性的创新，但五年生存率统计数据并没有像预期的那样得到改善，这表明了目前批准的诊断方法和疗法的挑战和局限性。这篇综述总结了过去二十年来为非小细胞肺癌治疗开发的各种创新疗法、治疗方案，以及目前非小细胞癌治疗领域的挑战和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.