Periods of psoriatic arthritis onset and diagnosis in Russian patients with moderate to severe psoriasis (according to psoriasis patient registry)

Q4 Medicine
E. Bogdanova, A. Kubanov
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引用次数: 1

Abstract

Background: Early detection of psoriatic arthritis in patients with psoriasis remains an unmet medical need. Early diagnosis and treatment initiation in patients with psoriatic arthritis decreases the risk of adverse outcomes and improves patients quality of life. Aims: to describe a period between psoriasis and psoriatic arthritis onset and a period between psoriatic arthritis onset and diagnosis in Russian patients with moderate to severe psoriasis. Materials and methods: analysis of data from the psoriasis patient registry. Patients aged 18 years and older with an established diagnosis of psoriasis and psoriatic arthritis were included in the analysis. Exclusion criteria: no data on timing of psoriatic arthritis onset or diagnosis. Results: sample size for the descriptive characteristic of period between psoriasis and psoriatic arthritis onset was 891 patients; sample size for the descriptive characteristic of period between psoriatic arthritis onset and diagnosis was 849 patients. Psoriatic arthritis onset preceeded cutaneous manifestation of psoriasis in 2.5% of patients. Concurrent onset of cutaneous psoriasis and psoriatic arthritis (within one year) had 10.7% of patients. In 86.8% of patients, cutaneous manifestation of psoriasis preceded manifestation of psoriatic arthritis. Exclusively of patients with psoriatic arthritis developed before or concurrently with cutaneous manifestation of psoriasis, the mean duration of period between psoriasis and psoriatic arthritis onset was 13.7 10.3 years, the median [IQR] 12 [6-19] years. In 24% of patients with psoriatic arthritis the was 1 year or more after its onset. On average, in this subgroup of patients, psoriatic arthritis was diagnosed 3.95.0 years after the signs and/or symptoms onset. Median [IQR] of period between psoriatic arthritis onset and diagnosis was 2 [1-4.5] years. Conclusions: a diagnostic delay in 24% Russian patients with psoriatic arthritis is one year or more. The average delay in diagnosis of psoriatic arthritis is about 4 years.
俄罗斯中重度银屑病患者的银屑病关节炎发作期和诊断(根据银屑病患者登记)
背景:银屑病患者早期发现银屑病关节炎仍然是一个未满足的医疗需求。银屑病关节炎患者的早期诊断和治疗可以降低不良后果的风险,提高患者的生活质量。目的:描述俄罗斯中重度银屑病患者银屑病和银屑病关节炎发作之间的时间段,以及银屑病关节炎发病和诊断之间的时间。材料和方法:分析银屑病患者登记处的数据。已确定诊断为银屑病和银屑病关节炎的18岁及以上患者被纳入分析。排除标准:没有关于银屑病关节炎发病或诊断时间的数据。结果:银屑病和银屑病关节炎发病时间的描述性特征样本量为891例;银屑病关节炎发病和诊断之间的描述特征的样本量为849名患者。在2.5%的患者中,银屑病关节炎的发病先于银屑病的皮肤表现。10.7%的患者同时发作皮肤银屑病和银屑病关节炎(一年内)。在86.8%的患者中,银屑病的皮肤表现先于银屑病关节炎的表现。不包括在银屑病皮肤表现之前或同时发生的银屑病关节炎患者,银屑病和银屑病关节炎发作之间的平均持续时间为13.710.3年,中位[IQR]12[6-19]年。24%的银屑病关节炎患者发病后1年或更长时间。平均而言,在这一亚组患者中,银屑病关节炎在体征和/或症状出现3.95.0年后被诊断为银屑病。银屑病关节炎发病和诊断之间的中位[IQR]为2[1-4.5]年。结论:24%的俄罗斯银屑病关节炎患者的诊断延迟为一年或一年以上。银屑病关节炎的诊断平均延迟约4年。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
40
审稿时长
8 weeks
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