Biocides Susceptibility of Clinically Isolated Escherichia coli in Presence and Without Organic Material

Abstract

Background and Aim: Hospital-acquired infections are considered a major health concern worldwide because of the increasing morbidity and mortality rate. Hence, selecting the most efficient disinfectants in a clinic is crucial. This study evaluated the antibacterial efficacy of seven mostly used disinfectants against clinically isolated Escherichia coli . Materials and Methods: For this purpose, minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of Aniosyme DD1 0.5%, Steranios 2%, Aniospray 29 and Surfanios 0.5% at Hazrat Valiasr hospital and PROSEPT ® Floor 0.75%, PROSEPT ® Instru 0.05% and PROSEPT ® Med used at Ayatollah Mousavi hospital were determined both in the presence and absence of bovine serum albumin (BSA) using microbroth dilution assay. Results: The results indicate that PROSEPT ® Med had the lowest MIC and MBC values, followed by Aniospray 29 and PROSEPT ® Instro, and the presence of BSA reduced antibacterial activities of disinfectants. Conclusion: The disinfectants applied at Ayatollah Mousavi hospital generally had higher antibacterial activities. Due to the importance of nosocomial pathogens at healthcare centers, selecting the most potent, fast-acting, and efficient disinfectants to prevent hospital-acquired infections is essential.