Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin

Abstract

69 Introduction Significant bone loss due to periodontal disease, tumors or cysts requires the alveolar bone reconstruction. Block-shaped bone substitute materials have been used clinically to fill large bone defects [1, 2]; however, their low shapeability leads to low operability. To improve their operability, paste-like bone filling agents (bone pastes) are anticipated to be developed as bone graft materials. Calcium phosphate bone paste has been already applied for clinical use [3, 4]; however, bone paste is non-absorbable and Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin