Suggestive Evidence of Slc2a9 Polymorphisms Association in Gouty Malay Males

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI:10.31436/IMJM.V14I2.432

W. Taib

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引用次数: 1

Abstract

Introduction: Solute carrier family 2, member 9 (SLC2A9) is thought to be an important urate transporter that influences the excretion and reabsorption of serum uric acid, thus has a strong effect on serum urate and risk of gout. SLC2A9 polymorphisms have been extensively studied in various populations in association with gout development. Our aim was to test for association of SLC2A9 SNPs with gout in Malay males. Methods: 78 gouty patients and 82 normal subjects were recruited and genotyped for rs3733591, rs5028843 and rs11942223 using PCR-RFLP technique. Single association and haplotype association analyses were conducted using SHEsis online software. Results: rs3733591 and rs5028843 showed association with gout with p value of 0.020 and 0.036, respectively, whilst rs11942223 yielded no association with p value of 0.08 with trend towards susceptibility projecting by OR=3.547, 3.667 and 2.732, respectively. It is noteworthy that haplotype 1/1/1 conferred protection in gout with p value 0.004 (OR=0.324 [0.147-0.716]). Conclusion: This study might suggest an evidence of association of SLC2A9 SNPs with gout among Malay males.

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Slc2a9多态性与高脂马来男性相关的提示性证据

简介：溶质载体家族2，成员9（SLC2A9）被认为是影响血清尿酸排泄和重吸收的重要尿酸盐转运蛋白，因此对血清尿酸盐和痛风风险有很强的影响。SLC2A9多态性已在不同人群中与痛风发展相关的广泛研究。我们的目的是测试SLC2A9 SNPs与马来男性痛风的相关性。方法：采用PCR-RFLP技术对78例痛风患者和82例正常人rs3733591、rs5028843和rs11942223进行基因分型。使用SHEsis在线软件进行单体关联和单倍型关联分析。结果：rs3733591和rs5028843与痛风相关，p值分别为0.020和0.036，而rs11942223与p值0.08无关，其易感性趋势分别为OR=3.547、3.667和2.732。值得注意的是，单倍型1/1/1在痛风中具有保护作用，p值为0.004（OR=0.324[0.147-0.716]）。结论：本研究可能提供了SLC2A9 SNPs与马来男性痛风相关的证据。

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来源期刊

International Medical Journal Malaysia Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： International Medical Journal Malaysia (IMJM) is the official journal of the Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia. It serves primarily as a forum for education and intellectual discourse for health professionals namely in clinical medicine but covers diverse issues relating to medical ethics, professionalism as well as medical developments and research in basic medical sciences. It also serves the unique purpose of highlighting issues and research pertaining to the Muslim world. Contributions to the IMJM reflect its international and multidisciplinary readership and include current thinking across a range of specialties, ethnicities and societies.

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