Identification of Human Papillomavirus genotypes in juvenile laryngeal papillomatosis. Three-year experience in a concentration hospital in Puebla, Mexico

Revista de la Facultad de Medicina Humana Pub Date : 2023-01-15 DOI:10.25176/rfmh.v23i1.5088

Arturo García-Galicia, Clotilde Margarita Andrade-Bonilla, V. Vallejo-Ruiz, Blanca Elena Vallejo-Domínguez, Janeth Ramírez-Mendoza, Á. Montiel-Jarquín, N. R. Bertado-Ramírez, J. Loría-Castellanos

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Abstract

Juvenile laryngeal papillomatosis (JLP) is a chronic benign disease of viral etiology, with an aggressive clinical course. In Mexico, the genotypes of the Human Papilloma Virus (HPV) that cause the disease have been poorly studied. The aim of this study was to identify HPV genotypes in PLJ patients. A descriptive and retrospective study was carried out, the records of patients with PLJ treated in a hospital in Mexico were reviewed, in the period 2018-2021. HPV was identied in all patients for genomes 6, 11, 16, and 18. 9 patients were included, 56% women, mean age 9.5 ± 5.7 years; 7 patients registered positivity for HPV-11 and 2 for HPV-6. The average age at diagnosis was 2.35 ± 1.77 years, with an average of 12 ± 11.56 surgical procedures. In conclusion, the most frequent genotypes in patients with PLJ were HPV-6 and HPV-11, with the latter predominating.ORIGINAL BREVES

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人乳头瘤病毒基因型在幼年喉部乳头状瘤病中的鉴定。在墨西哥普埃布拉的一家集中医院工作了三年

青少年喉部乳头状瘤病(JLP)是一种慢性良性疾病的病毒性病因，具有侵略性的临床过程。在墨西哥，引起该疾病的人乳头瘤病毒(HPV)的基因型研究很少。本研究的目的是确定PLJ患者的HPV基因型。我们进行了一项描述性和回顾性研究，回顾了2018-2021年期间在墨西哥一家医院治疗的PLJ患者的记录。在所有患者的基因组6、11、16和18中都发现了HPV。纳入9例患者，女性56%，平均年龄9.5±5.7岁;7例HPV-11阳性，2例HPV-6阳性。平均诊断年龄2.35±1.77岁，平均手术次数12±11.56次。总之，在PLJ患者中最常见的基因型是HPV-6和HPV-11，以后者为主。原始BREVES

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Revista de la Facultad de Medicina Humana

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审稿时长

12 weeks