Review on Methods Used to Determine Antioxidant Activity of Origanum majorana

Abstract

Presence of free radicals in human body are harmful and cell systems are induce many diseases like cardiovascular, diabetes, cancer, inflammation, neuro-degenerative disorder, atherosclerosis, cataract, etc. Antioxidants can balance the effect of free radicals. Antioxidant-rich herbs are identified for preparation of drugs that can be administered to neutralize the free radicals. In the present context the selected medicinal plant is “Origanum majorana” (Family- Lamiaceae) widely known as Marwa in India sub-continent. As the medical professionals show their desires towards composite or lateral treatment, application of drugs with herbal origin gained its importance. This review presented various in vitro and in vivo methods used in the antioxidant activity study of O.majorana and observed its efficacy to reduce oxidative stress. Referred many reliable sources like Research gate, PubMed, Science Direct, Google scholar, Wiley online library, books to collect all information about the antioxidant activity of the selected plant. Used several methods to determine the antioxidants activity of O.majorana, such as superoxide radical scavenging, ferric ion reducing antioxidant potency, thiobarbituric acid reactive substances, hydrogen peroxide scavenging, hydroxyl radical scavenging, lipid peroxidation inhibition, etc. The selected plant contains many phytoconstituents such as gallic acid, ferulic acid, apigenin, catechin, rutin, quercetin, luteolin, linolenic acid, β-sitosterol, and essential oils, which may be responsible for antioxidant activity. The review article provides information for investigating and developing new antioxidant methods and major phytoconstituents from O.majorana for better therapy of oxidative stress-mediated complications.