Toward “off-the-shelf” allogeneic CAR T cells

Blake T. Aftab, Barbra Sasu, Janani Krishnamurthy, Eric Gschweng, Vincent Alcazer, Stéphane Depil
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引用次数: 24

Abstract

Chimeric antigen receptor (CAR) T cell therapy represents a major breakthrough in the field of immuno-oncology. Many potential issues are apparent for autologous CAR T cell therapy, such as time for manufacturing and need for interim therapies in progressing patients, wide variations in terms of quality and quantity of T cells, and difficulty to obtain enough cells for redosing. “Off-the-shelf” allogeneic CAR T cells premanufactured from third-party donors may theoretically provide solutions to these different problems. However, allogeneic T cells possess foreign immunological identities that can lead to histocompatibility considerations such as graft-versus-host disease and rejection of allogeneic cells. This review outlines the major recent advances for off-the-shelf T cell therapies currently in clinical trials or in preclinical development and describes strategies for reengineering or selecting specific T cell immune identities to create safe and efficient immunotherapies for patients.

Abstract Image

走向“现成的”同种异体CAR - T细胞
嵌合抗原受体(CAR) T细胞治疗是免疫肿瘤学领域的重大突破。自体CAR - T细胞治疗的许多潜在问题是显而易见的,例如制造时间和进展患者需要临时治疗,T细胞质量和数量的广泛差异,以及难以获得足够的细胞进行重新给药。从理论上讲,从第三方供体预先制造的“现成的”同种异体CAR - T细胞可能为这些不同的问题提供解决方案。然而,同种异体T细胞具有外来免疫特性,这可能导致组织相容性方面的考虑,如移植物抗宿主病和同种异体细胞的排斥。本文概述了目前临床试验或临床前开发的现成T细胞疗法的最新进展,并描述了重组或选择特定T细胞免疫身份的策略,以为患者创造安全有效的免疫疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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