Role of Innate Immune Cells in Chronic Diabetic Wounds

IF 1.8 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES
Jayashree Vijaya Raghavan, Siddharth Jhunjhunwala
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引用次数: 0

Abstract

Diabetic foot ulcers are one of the common secondary complications associated with diabetes and are characterized by delayed or absence of healing. Of the several factors contributing to poor healing, chronic low-grade inflammation significantly worsens wound healing resulting in adverse outcomes. As the innate immune system plays a vital role in wound healing, a closer look at their alterations may provide insights into developing novel treatment strategies to promote healing. In this review, we discuss the role of the innate immune system in driving chronic inflammation both at the wound site and at the systemic level, resulting in poor healing outcomes. Specifically, we highlight the findings from preclinical and clinical studies that describe the dysregulations of the innate system at the cellular and molecular level and how they contribute to low-grade chronic inflammation in wounds. Our review of the literature shows that preexisting low-grade inflammation, which is associated with altered myeloid cell phenotype and function, is key to impaired wound healing responses in individuals with diabetes. Hence, we suggest that modulating circulating myeloid cell function and low-grade chronic inflammation could be a helpful strategy in promoting diabetic foot ulcer healing.

Abstract Image

先天免疫细胞在慢性糖尿病伤口中的作用
糖尿病足溃疡是与糖尿病相关的常见继发性并发症之一,其特征是愈合延迟或没有愈合。在导致愈合不良的几个因素中,慢性低度炎症显著恶化伤口愈合,导致不良后果。由于先天免疫系统在伤口愈合中起着至关重要的作用,仔细观察它们的变化可能会为开发新的治疗策略提供见解,以促进愈合。在这篇综述中,我们讨论了先天免疫系统在伤口部位和全身水平上驱动慢性炎症的作用,导致不良的愈合结果。具体来说,我们强调临床前和临床研究的发现,这些研究描述了细胞和分子水平上先天系统的失调,以及它们是如何导致伤口低度慢性炎症的。我们对文献的回顾表明,先前存在的与髓细胞表型和功能改变相关的低级别炎症是糖尿病患者伤口愈合反应受损的关键。因此,我们建议调节循环髓细胞功能和低级别慢性炎症可能是促进糖尿病足溃疡愈合的有用策略。
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来源期刊
Journal of the Indian Institute of Science
Journal of the Indian Institute of Science MULTIDISCIPLINARY SCIENCES-
CiteScore
4.30
自引率
0.00%
发文量
75
期刊介绍: Started in 1914 as the second scientific journal to be published from India, the Journal of the Indian Institute of Science became a multidisciplinary reviews journal covering all disciplines of science, engineering and technology in 2007. Since then each issue is devoted to a specific topic of contemporary research interest and guest-edited by eminent researchers. Authors selected by the Guest Editor(s) and/or the Editorial Board are invited to submit their review articles; each issue is expected to serve as a state-of-the-art review of a topic from multiple viewpoints.
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