Fenugreek (Trigonella foenum-graecum L.) modulates energy metabolism and anti-inflammatory response in obesity via combinatorial analysis

Abstract

Since ancient times, fenugreek has been utilized as a dietary condiment as well as for its various therapeutic properties. The goal of this study is to look at the function of fenugreek in regulating obesity metabolism by providing a global picture of gene networks and pathways. The buildup of fat in adipose tissue and other internal organs is a hallmark of obesity, a long-term carbohydrate and lipid metabolic disorder. The fenugreek plant grows up to 60 cm tall, with golden-yellow rhomboidal seeds. Though the seeds of fenugreek are more well-known, the leaves and stems have also been suggested to have therapeutic properties. Various studies have shown that the secondary metabolites in the fenugreek plant are responsible for these properties. Several studies have shown that fenugreek has anti-obesity properties, making it a good plant candidate with a high prospect of being used to treat obesity. This review paper discusses the use of combinatorial analytic approaches to better understand the medicinal uses of fenugreek. Combinatorial analytical methods that use functional modulation and modelling may make it easier to come up with research strategies to fill in research gaps and find possible research niches.