Callignan A, A New Neolignan from the Leaves of Callicarpa kwangtungensis

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2023-08-15 DOI:10.25135/rnp.408.2307.2832

Hancheng Ren, Weiqiang Fei

引用次数: 0

Abstract

: In the current study, a new lignan ( 1 ), named callignan, as well as two known ones ( 2 and 3 ), were obtained from the EtOAc extract of the leaves of Callicarpa kwangtungensis . The structure elucidation of 1 was conducted by detailed interpretation of the 1D and 2D NMR spectroscopic data. Optical rotation of compound 1 and ECD data revealed that the compound was a racemic compound. Compounds 1 − 3 showed moderate effects with IC 50 values of 46, 29, and 42  M on NO production in LPS-induced RAW 264.7 cell inflammation model.

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广东紫珠叶中新木脂素Callignan A

本研究从光通珠兰(Callicarpa kwangtungensis)叶的乙酸乙酯提取物中分离得到一种新的木脂素(1)和两种已知的木脂素(2和3)。通过详细解释一维和二维核磁共振波谱数据，对1的结构进行了解析。化合物1的旋光性和ECD数据表明该化合物为外消旋化合物。化合物1−3的IC 50值为46、29和42M时，对lps诱导的RAW 264.7细胞炎症模型的NO生成有中等影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.