Study on rapid eye movement sleep behavior disorder in patients with Parkinson's disease at early stage

Q4 Medicine

中国现代神经疾病杂志 Pub Date : 2017-10-25 DOI:10.3969/cjcnn.v17i10.1674

Hui-li Zou, Xianchao Zhao, Yingcong Jiang, Ge-sheng Lei, Weiyi Yang, C. Su

{"title":"Study on rapid eye movement sleep behavior disorder in patients with Parkinson's disease at early stage","authors":"Hui-li Zou, Xianchao Zhao, Yingcong Jiang, Ge-sheng Lei, Weiyi Yang, C. Su","doi":"10.3969/cjcnn.v17i10.1674","DOIUrl":null,"url":null,"abstract":"Objective To investigate the incidence, occurrence time and electrophysiological characteristics of rapid eye movement behavior disorder (RBD) in patients with early Parkinson's disease (PD), and the characteristics of motor symptoms and non . motor symtoms (NMS). Methods Sixty PD patients were divided into PD + RBD group (N = 42) and control group (N = 18) according to whether they were complicated with RBD or not. Unified Parkinson's Disease Rating Scale (UPDRS)Ⅱ andⅢ, Hoehn-Yahr Stage, Montreal Cognitive Assessment (MoCA), Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), RBD Screening Questionnaire (RBDSQ), Epworth Sleepiness Scale (ESS) and polysomnography (PSG) were used in 60 patients. Results Among 60 patients, 42 (70% ) were accompanied by RBD. PSG showed that PD + RBD patients mainly presented upper limb stretching and gripping, body twitching, laughing, shouting, cursing and other non.violent actions, except 2 cases presented violent actions, such as hitting, kicking, etc. In PD + RBD group, the age was older (P = 0.024), duration was longer (P = 0.000), and UPDRSⅡ (P = 0.005)，UPDRSⅢ(P = 0.001), the scale values of Hoehn-Yahr Sotage 2 (P = 0.007), anxiety (P = 0.044) and depression (P = 0.001) ratio were all higher than control group. There were significant differences in density of mandible myoelectric activity (P = 0.000) and ratio of rapid eye movement (REM) without atonia (P = 0.000) between 2 groups. In PD + RBD group, 16 patients (38.10% ) had symptoms of RBD, earlier than PD occurred 5.20 (3.91, 6.51) years. Conclusions PD patients with older age, longer duration, more severe motor symptoms and non?motor symptoms were more likely to be accompanied by RBD. The severity of RBD in PD patients accompanied with RBD is higher than that in PD without RBD. RBD may be the early manifestation of PD. PSG has important value in the diagnosis of PD with RBD. DOI: 10.3969/j.issn.1672-6731.2017.10.006","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"736-740"},"PeriodicalIF":0.0000,"publicationDate":"2017-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国现代神经疾病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3969/cjcnn.v17i10.1674","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To investigate the incidence, occurrence time and electrophysiological characteristics of rapid eye movement behavior disorder (RBD) in patients with early Parkinson's disease (PD), and the characteristics of motor symptoms and non . motor symtoms (NMS). Methods Sixty PD patients were divided into PD + RBD group (N = 42) and control group (N = 18) according to whether they were complicated with RBD or not. Unified Parkinson's Disease Rating Scale (UPDRS)Ⅱ andⅢ, Hoehn-Yahr Stage, Montreal Cognitive Assessment (MoCA), Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), RBD Screening Questionnaire (RBDSQ), Epworth Sleepiness Scale (ESS) and polysomnography (PSG) were used in 60 patients. Results Among 60 patients, 42 (70% ) were accompanied by RBD. PSG showed that PD + RBD patients mainly presented upper limb stretching and gripping, body twitching, laughing, shouting, cursing and other non.violent actions, except 2 cases presented violent actions, such as hitting, kicking, etc. In PD + RBD group, the age was older (P = 0.024), duration was longer (P = 0.000), and UPDRSⅡ (P = 0.005)，UPDRSⅢ(P = 0.001), the scale values of Hoehn-Yahr Sotage 2 (P = 0.007), anxiety (P = 0.044) and depression (P = 0.001) ratio were all higher than control group. There were significant differences in density of mandible myoelectric activity (P = 0.000) and ratio of rapid eye movement (REM) without atonia (P = 0.000) between 2 groups. In PD + RBD group, 16 patients (38.10% ) had symptoms of RBD, earlier than PD occurred 5.20 (3.91, 6.51) years. Conclusions PD patients with older age, longer duration, more severe motor symptoms and non?motor symptoms were more likely to be accompanied by RBD. The severity of RBD in PD patients accompanied with RBD is higher than that in PD without RBD. RBD may be the early manifestation of PD. PSG has important value in the diagnosis of PD with RBD. DOI: 10.3969/j.issn.1672-6731.2017.10.006

查看原文本刊更多论文

帕金森病早期快速眼动睡眠行为障碍的研究

目的探讨早期帕金森病(PD)患者快速眼动行为障碍(RBD)的发生率、发生时间及电生理特征，以及运动症状和非运动症状的特点。运动症状(NMS)方法60例PD患者根据是否合并RBD分为PD + RBD组(N = 42)和对照组(N = 18)。采用统一帕金森病评定量表(UPDRS)Ⅱ和Ⅲ、Hoehn-Yahr分期、蒙特利尔认知评定量表(MoCA)、汉密尔顿焦虑评定量表(HAMA)、汉密尔顿抑郁评定量表(HAMD)、RBD筛查问卷(RBDSQ)、Epworth嗜睡量表(ESS)和多道睡眠描记仪(PSG)对60例患者进行分析。结果60例患者中，42例(70%)伴有RBD。PSG显示PD + RBD患者主要表现为上肢伸展和抓握、身体抽搐、笑、喊、骂等非。暴力行为，除2例为暴力行为，如打人、踢人等。PD + RBD组患者年龄较大(P = 0.024)，病程较长(P = 0.000)， UPDRSⅡ(P = 0.005)、UPDRSⅢ(P = 0.001)、Hoehn-Yahr Sotage 2量表值(P = 0.007)、焦虑(P = 0.044)、抑郁(P = 0.001)比值均高于对照组。两组患者下颌骨肌电活动密度(P = 0.000)和无张力快速眼动(REM)比例(P = 0.000)差异均有统计学意义。PD + RBD组有16例(38.10%)患者出现RBD症状，比PD早发生5.20年(3.91年，6.51年)。结论PD患者年龄较大，病程较长，运动症状较重，且无明显症状。运动症状更可能伴有RBD。伴有RBD的PD患者RBD的严重程度高于无RBD的PD患者。RBD可能是PD的早期表现。PSG对PD合并RBD的诊断有重要价值。DOI: 10.3969 / j.issn.1672-6731.2017.10.006

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊