{"title":"What is a Bladder Cancer Molecular Subtype?","authors":"Mattias Höglund","doi":"10.3233/BLC-220124","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Several molecular classification systems for bladder cancer have been proposed, but due to differences on how to define molecular subtypes, controversies and misunderstandings have arisen.</p><p><strong>Objective: </strong>To discuss different aspects of the molecular classification of bladder cancer and to point to the consequences of using different conceptual approaches. To question some underlying assumptions when defining molecular subtypes.</p><p><strong>Methods: </strong>To critically reflect on some of the principles and methods used when defining molecular subtypes.</p><p><strong>Results: </strong>Depending on underlying assumptions and aims for the definitions of subtypes, different types of molecular subtypes will be arrived at.</p><p><strong>Conclusion: </strong>The underlying assumptions and their consequences must be better clarified when defining molecular subtypes.</p>","PeriodicalId":54217,"journal":{"name":"Bladder Cancer","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11165936/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bladder Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3233/BLC-220124","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Several molecular classification systems for bladder cancer have been proposed, but due to differences on how to define molecular subtypes, controversies and misunderstandings have arisen.
Objective: To discuss different aspects of the molecular classification of bladder cancer and to point to the consequences of using different conceptual approaches. To question some underlying assumptions when defining molecular subtypes.
Methods: To critically reflect on some of the principles and methods used when defining molecular subtypes.
Results: Depending on underlying assumptions and aims for the definitions of subtypes, different types of molecular subtypes will be arrived at.
Conclusion: The underlying assumptions and their consequences must be better clarified when defining molecular subtypes.
期刊介绍：
Bladder Cancer is an international multidisciplinary journal to facilitate progress in understanding the epidemiology/etiology, genetics, molecular correlates, pathogenesis, pharmacology, ethics, patient advocacy and survivorship, diagnosis and treatment of tumors of the bladder and upper urinary tract. The journal publishes research reports, reviews, short communications, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that expedites our fundamental understanding and improves treatment of tumors of the bladder and upper urinary tract.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
