Adverse effects of amphotericin B deoxycholate in neonates of the National Hospital of Itauguá

Abstract

Introduction: in recent decades, the agent of choice for the treatment of Artículo original Efectos adversos de anfotericina B desoxicolato en neonatos del Hospital Nacional de Itauguá Adverse effects of amphotericin B deoxycholate in neonates of the National Hospital of Itauguá Patricia Abigail Arias Yrazusta, Gladys Godoy Torales, Gloria Samudio, Chantal Marie Real Aparicio DEL NACIONAL Rev. Nac (Itauguá) 2018;10(1):017-035 10.18004/rdn2018.0010.01.017-035 most systemic mycoses has been amphotericin B which, despite the toxic effects, continues to play an important role in the treatment of fungal infections. Objective: to determine the adverse effects associated with the use of amphotericin B in neonates of the Neonatology Service of the National Hospital of Itauguá, in the period 2013 2015. Materials and methods: retrospective case series study of newborns treated with amphotericin B. Results: among 28 newborns treated with amphotericin B, there was a higher prevalence in males. With regard to age, more than half of the newborns were pre-term in the group studied. There was a predominance of low birth weight (32.14%). The risk factors showed that 53.5% did not have a history of sepsis. The mean age of onset of amphotericin was 19 ± 9 days, more than half of the infants used progressive dose from 0.5 mg / kp / day to 1 mg / kp / day, in 24 hours. 96.4% received infusion of amphotericin B for 4 hours, 1 case required 6 hours. Among the side effects, 35.7% of the patients presented anemia, the most frequent water and electrolyte disturbance was hypokalemia, among the signs were tachycardia and hypotension. Conclusions: the most striking side effects found during treatment with amphotericin B were anemia, Sodium and Potassium alterations.