Elahe Karami Raviz, Fatemeh Noormand, Ali Sharifzadeh Kermani, Ali Galedari, K. Esmaeilpour, M. Maneshian, T. Kalantaripour, S. Dabiri, M. A. Shekaari
{"title":"Promising effects of naringenin and melatonin against hepatic encephalopathy impairments induced by bile duct ligation in male rats.","authors":"Elahe Karami Raviz, Fatemeh Noormand, Ali Sharifzadeh Kermani, Ali Galedari, K. Esmaeilpour, M. Maneshian, T. Kalantaripour, S. Dabiri, M. A. Shekaari","doi":"10.2174/1871524922666220314123052","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nBile duct ligation (BDL) has been used for evaluating the protective effects of different agents with anti-inflammatory and antioxidant properties against the liver and brain damages. Naringenin (N) and melatonin (M) were used as protectants in various models of diseases.\n\n\nAIM\nIn the current research, the combinational effects of these well-known anti-inflammatory and antioxidants agents were investigated against cerebral injuries induced by BDL in male rats.\n\n\nMETHODS\nThe animals were distributed into the following groups: Sham, BDL + Vehicle and BDL+ N + M. Neuronal damages were evaluated using biochemical, motor behavioral tasks and morphological assessments. <p.\n\n\nRESULTS\nBased on the data, BDL resulted in the decreasing locomotor activity, which was reversed by N and M. Morphological study confirmed that BDL led to neurodegeneration in the cortex of the rats, and the N and M treatment preserved cortical neurons. In addition, immunohistochemical (IHC) study of the rat cortex showed that BDL resulted in increasing the activated astrocytes, and the N and M treatment reduced the number of activated cells.\n\n\nCONCLUSION\nThese results obviously depicted that combinational therapy with N and M had positive effects in the BDL rats, probably due to their synergistic anti-inflammatory and antioxidant activities.","PeriodicalId":9799,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central nervous system agents in medicinal chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871524922666220314123052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Psychology","Score":null,"Total":0}
引用次数: 1
Abstract
BACKGROUND
Bile duct ligation (BDL) has been used for evaluating the protective effects of different agents with anti-inflammatory and antioxidant properties against the liver and brain damages. Naringenin (N) and melatonin (M) were used as protectants in various models of diseases.
AIM
In the current research, the combinational effects of these well-known anti-inflammatory and antioxidants agents were investigated against cerebral injuries induced by BDL in male rats.
METHODS
The animals were distributed into the following groups: Sham, BDL + Vehicle and BDL+ N + M. Neuronal damages were evaluated using biochemical, motor behavioral tasks and morphological assessments.
期刊介绍:
Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.