Metanephrine and Normetanephrine Urine Excretion in Patients with PCOS

Q4 Medicine

Acta Medica Bulgarica Pub Date : 2022-06-01 DOI:10.2478/amb-2022-0012

R. Robeva, N. Arnaudova, G. Kirilov, A. Elenkova, S. Zacharieva

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引用次数: 1

Abstract

Abstract Aims: The present study aims to investigate the association between catecholamine metabolites (normetanephrine [NMN] and metanephrine [MN]) and polycystic ovarian syndrome (PCOS) and its clinical manifestations. Materials and methods: A total of 60 female patients (18-37 years) were included in the study. Twenty-five healthy women and 35 patients with PCOS provided blood and urine samples. Anthropometric, biochemical, and hormonal parameters, e.g. immunoreactive insulin, total testosterone, gonadotropins, and dehydroepiandrosterone-sulfate (DHEAS) have been investigated. Twenty-four-hour urinary metanephrines (MN and NMN) were measured by radioimmunoassay technique. Results: MN and NMN showed a strong positive correlation (r = +0.645, p < 0.001) in women with PCOS, but nephrines were not significantly associated with the hormonal, anthropometric, and metabolic parameters of the patients (p > 0.05 for all). No differences in urinary nephrines concentrations between women with PCOS and healthy individuals after adjustment for age and BMI were established. However, lower 24-hour urinary MN levels predicted the development of menstrual irregularity after adjustment for age and BMI (OR = 1,015 [95% CI 1,001-1,029], p = 0,036). Conclusions: Adrenomedullary dysfunction might influence the development of chronic anovulation in young women.

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多囊卵巢综合征患者尿中的中肾上腺素和中肾上腺素排泄

摘要目的:本研究旨在探讨儿茶酚胺代谢物(去甲肾上腺素[NMN]和去甲肾上腺素[MN])与多囊卵巢综合征(PCOS)及其临床表现的关系。材料与方法:共纳入60例女性患者，年龄18-37岁。25名健康女性和35名多囊卵巢综合征患者提供了血液和尿液样本。人体测量、生化和激素参数，如免疫反应性胰岛素、总睾酮、促性腺激素和硫酸脱氢表雄酮(DHEAS)已被调查。用放射免疫法测定24小时尿中肾上腺素(MN、NMN)。结果:MN和NMN在PCOS患者中呈强正相关(r = +0.645, p < 0.001)，而肾素与患者的激素、人体测量和代谢参数无显著相关性(p < 0.05)。经年龄和BMI调整后，PCOS女性与健康个体尿肾素浓度无差异。然而，在调整年龄和BMI后，较低的24小时尿MN水平预示着月经不规律的发生(OR = 1,015 [95% CI 1,001-1,029]， p = 0,036)。结论:肾上腺髓质功能障碍可能影响年轻女性慢性无排卵的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.