Role of the Gut Microbiota in Celiac Disease: An Update

Abstract

Celiac disease (CD) is a chronic, autoimmune disease secondary to the gluten ingestion, or more specifically gliadin molecules, developing in genetically predisposed individuals. Recent metagenomic and metabolomic studies provide unprecedented information on the major involvement of the gut microbiota in CD. In this review, we describe the main features of the gut microbiota interfering with the onset and development of CD, as well as its potential implication in CD prevention.