Anti-human ovarian cancer and cytotoxicity effects of nickel nanoparticles green-synthesized by Alhagi maurorum leaf aqueous extract

IF 2.6 4区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of Experimental Nanoscience Pub Date : 2022-03-11 DOI:10.1080/17458080.2021.2011860

C. Yuan, B. Jiang, Xiaocui Xu, Yunjie Wan, Li Wang, Jia Chen

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引用次数: 8

Abstract

Abstract Alhagi maurorum (camelthorn) is one of the popular medicinal plants. The plant has many pharmaceutical uses in traditional medicine. In this study, nickel nanoparticles were synthesized according to green chemistry rules using the aqueous extract of A. maurorum. The green-synthesized NiNPs were characterized using different techniques such as EDX, FE-SEM, XRD, UV–vis and FT-IR. The FE-SEM results confirm spherical morphology for the nanoparticles with size of 20.56–36.63 nm. In the oncological part of the present study, the treated cells with NiNPs were assessed by MTT assay for 48 h about the cytotoxicity and anti-human ovarian cancer properties on normal (HUVEC) and ovarian cancer cell lines i.e. OVCAR-3, ES-2, TOV-21G, OV-90 and UWB1.289. The viability of malignant ovarian cell lines reduced dose-dependently in the presence of NiNPs. The IC50 of NiNPs was 191, 312, 250, 396 and 241 µg/mL against OVCAR-3, ES-2, TOV-21G, OV-90 and UWB1.289 cell lines respectively.

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毛叶提取物绿合成纳米镍抗人卵巢癌症及细胞毒性研究

摘要骆驼蓬是一种很受欢迎的药用植物。这种植物在传统医药中有许多药用用途。在本研究中，根据绿色化学规则，使用毛白杨的水提取物合成了镍纳米颗粒。使用EDX、FE-SEM、XRD、UV–vis和FT-IR等不同技术对绿色合成的NiNPs进行了表征。FE-SEM结果证实了尺寸为20.56–36.63的纳米颗粒的球形形态 nm。在本研究的肿瘤学部分，用MTT法评估用NiNPs处理的细胞48 h关于正常（HUVEC）和卵巢癌症细胞系，即OVCAR-3、ES-2、TOV-21G、OV-90和UWB1.289的细胞毒性和抗人卵巢癌症特性。在存在NiNPs的情况下，恶性卵巢细胞系的生存能力呈剂量依赖性降低。NiNP的IC50分别为191、312、250、396和241 µg/mL分别对抗OVCAR-3、ES-2、TOV-21G、OV-90和UWB1.289细胞系。

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来源期刊

Journal of Experimental Nanoscience 工程技术-材料科学：综合

CiteScore

4.10

自引率

25.00%

发文量

审稿时长

6.5 months

期刊介绍： Journal of Experimental Nanoscience, an international and multidisciplinary journal, provides a showcase for advances in the experimental sciences underlying nanotechnology and nanomaterials. The journal exists to bring together the most significant papers making original contributions to nanoscience in a range of fields including biology and biochemistry, physics, chemistry, chemical, electrical and mechanical engineering, materials, pharmaceuticals and medicine. The aim is to provide a forum in which cross fertilization between application areas, methodologies, disciplines, as well as academic and industrial researchers can take place and new developments can be encouraged.