Polyurethane/ drug loaded halloysite nanotubes based electrospun nanocomposite for sustained drug release

IF 1.7 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advances in Natural Sciences: Nanoscience and Nanotechnology Pub Date : 2023-03-01 DOI:10.1088/2043-6262/acc454

M. Joshi, Sukumar Roy, V. Venugopal

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Abstract

In this study, electrospun polyurethane nanofibre composite incorporated with drug loaded halloysite nanotubes is presented. Chlorhexidine acetate (CA) drug was loaded into the halloysite nanotubes (HNT) to facilitate its controlled release for prolonged efficacy. The drug loading percentage in HNT was determined using thermo-gravimetric (TG) analysis. Uniform fibrous webs were obtained by electrospinning technique with optimised process parameters (i.e., 10 KV, flow rate of 5 μl min−1 and needle to collector distance of 10 cm) which was evident from SEM images. Antimicrobial efficiency of the nanowebs was determined using disk diffusion method (AATCC 90) against both the Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria. The polyurethane/HNT-CA nanowebs showed very good activity against these strains. The drug release analysis of the nanowebs was carried by UV–vis spectrophotometry using total immersion method. The nanocomposite with drug loaded in HNT showed higher controlled release characteristics as evident from the drug release assay.

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聚氨酯/药物负载halloysite纳米管基电纺纳米复合材料的药物缓释

在本研究中，提出了电纺聚氨酯纳米纤维复合材料与药物负载的halloystite纳米管。将醋酸氯己定（CA）药物加载到羟基磷灰石纳米管（HNT）中，以促进其控制释放，从而延长疗效。采用热重分析法测定HNT中的药物负载百分比。通过静电纺丝技术获得了均匀的纤维网，优化的工艺参数（即10 KV，流速为5μl min−1，针与收集器的距离为10 cm）从SEM图像中可以明显看出。使用圆盘扩散法（AATCC90）测定纳米网对革兰氏阳性（金黄色葡萄球菌）和革兰氏阴性（大肠杆菌）细菌的抗菌效率。聚氨酯/HNT-CA纳米网对这些菌株表现出非常好的活性。采用全浸泡法，通过紫外-可见分光光度法对纳米网进行药物释放分析。载药于HNT的纳米复合材料显示出更高的控释特性，这从药物释放测定中可以明显看出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Natural Sciences: Nanoscience and Nanotechnology NANOSCIENCE & NANOTECHNOLOGYMATERIALS SCIE-MATERIALS SCIENCE, MULTIDISCIPLINARY

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