Serum and Salivary Vitamin B12 Levels among Iron Deficiency Anemia Patient with Recurrent Aphthous Stomatitis: An Analytical Cross-Sectional Study

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Hypotheses Pub Date : 2023-04-01 DOI:10.4103/denthyp.denthyp_59_23

Ghaith Al-hamdani, L. Yas

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引用次数: 1

Abstract

Introduction: We aimed to evaluate serum and salivary vitamin B12 levels in patients with iron deficiency anemia (IDA) with and without recurring aphthous ulcers (RAS). Methods: Study participants were divided into three groups, clinically healthy control group (n = 25), an IDA patient with RAS (n = 25), and an IDA without RAS (n = 25). The enzyme-linked immunosorbent assay (ELISA) method was used to assess the serum and salivary B-12 levels blindly. Data analyses were performed using one-way ANOVA and the Tukey’s post hoc test using R software. Result: There were statistically significant differences regarding serum and salivary B12 levels among study groups (P<0.001). All pairwise comparisons showed significant differences regarding serum (P<0.001) and salivary (P ≤ 0.002) B12 levels. Conclusion: The Control group (396 ± 18.2 pg/mL) was within the normal serum level of vitamin B12 (200-900 pg/mL), while in IDA with RAS (111 ± 15.4 pg/mL) and IDA without RAS (145 ± 57.2 pg/mL) serum level of vitamin B12 is lower than the normal range and significantly lower than the control group.

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缺铁性贫血伴复发性口腔炎患者血清和唾液维生素B12水平:一项分析性横断面研究

引言：我们旨在评估伴有和不伴有复发性阿弗他溃疡（RAS）的缺铁性贫血（IDA）患者的血清和唾液维生素B12水平。方法：将受试者分为三组，临床健康对照组（n = 25），患有RAS的IDA患者（n = 25）和不含RAS的IDA（n = 25）。采用酶联免疫吸附试验（ELISA）方法对血清和唾液中B-12水平进行盲法测定。使用单因素方差分析和使用R软件的Tukey事后检验进行数据分析。结果：研究组之间血清和唾液B12水平存在统计学显著差异（P＜0.001）。所有成对比较显示血清（P＜001）和唾液（P≤0.002）B12水平存在显著差异。结论：对照组（396 ± 18.2 pg/mL）在维生素B12的正常血清水平（200-900 pg/mL），而在患有RAS的IDA中（111 ± 15.4 pg/mL）和不含RAS的IDA（145 ± 57.2 pg/mL）血清维生素B12水平低于正常范围且显著低于对照组。

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