A potential role for psilocybin in the treatment of obsessive-compulsive disorder

IF 2.2 Q3 PHARMACOLOGY & PHARMACY
E. Jacobs
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引用次数: 2

Abstract

The recent revivification of interest in the therapeutic use of psychedelics has had a particular focus on mood disorders and addiction, although there is reason to think these drugs may be effective more widely. After outlining pertinent aspects of psilocybin and obsessive-compulsive disorder (OCD), the current review summarizes the evidence indicating that there may be a role for psilocybin in the treatment of OCD, as well as highlighting a range of potential therapeutic mechanisms that reflect the action of psilocybin on brain function. Although the current evidence is limited, that multiple signals point in directions consistent with treatment potential, alongside the psychological and physiological safety of clinically administered psilocybin, support the expansion of research, both in animal models and in further randomized controlled trials, to properly investigate this potential.
裸盖菇素在治疗强迫症中的潜在作用
最近,人们对迷幻药治疗用途的兴趣再次高涨,特别关注情绪障碍和成瘾,尽管有理由认为这些药物可能更广泛地有效。在概述了裸盖菇素和强迫症(OCD)的相关方面后,本综述总结了表明裸盖菇蛋白可能在治疗强迫症中发挥作用的证据,并强调了一系列潜在的治疗机制,这些机制反映了裸盖菌素对大脑功能的作用。尽管目前的证据有限,但多个信号指向与治疗潜力一致的方向,以及临床给药裸盖菇素的心理和生理安全性,支持在动物模型和进一步的随机对照试验中扩大研究范围,以正确研究这种潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Psychedelic Studies
Journal of Psychedelic Studies Social Sciences-Anthropology
CiteScore
2.50
自引率
8.90%
发文量
20
审稿时长
26 weeks
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